FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy

Hepatotoxicity is a common side effect for patients treated with gefitinib, but the related pathogenesis is unclear and lacks effective predictor and management strategies. A multi-omics approach integrating pharmacometabolomics, pharmacokinetics and pharmacogenomics was employed in non-small cell l...

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Detalles Bibliográficos
Autores principales: Guan, Shaoxing, Chen, Xi, Chen, Youhao, Wan, Guohui, Su, Qibiao, Liang, Heng, Yang, Yunpeng, Fang, Wenfeng, Huang, Yan, Zhao, Hongyun, Zhuang, Wei, Liu, Shu, Wang, Fei, Feng, Wei, Zhang, Xiaoxu, Huang, Min, Wang, Xueding, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513443/
https://www.ncbi.nlm.nih.gov/pubmed/36176901
http://dx.doi.org/10.1016/j.apsb.2022.02.006

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