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Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice

This study aimed to examine the chemical and anti-aging properties of chicken essence (CE) prepared with Sesamum indicum, Angelica acutiloba, and Zingiber officinale (HCE). HCE was analyzed for nutritional and phytochemical composition, and its anti-aging effects were investigated on the D-galactose...

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Autores principales: Wu, Shu-Jing, Tung, Yi-Jou, Yen, Ming-Hong, Ng, Lean-Teik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513449/
https://www.ncbi.nlm.nih.gov/pubmed/36176640
http://dx.doi.org/10.3389/fnut.2022.989067
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author Wu, Shu-Jing
Tung, Yi-Jou
Yen, Ming-Hong
Ng, Lean-Teik
author_facet Wu, Shu-Jing
Tung, Yi-Jou
Yen, Ming-Hong
Ng, Lean-Teik
author_sort Wu, Shu-Jing
collection PubMed
description This study aimed to examine the chemical and anti-aging properties of chicken essence (CE) prepared with Sesamum indicum, Angelica acutiloba, and Zingiber officinale (HCE). HCE was analyzed for nutritional and phytochemical composition, and its anti-aging effects were investigated on the D-galactose (Gal)-induced aging mice. Results showed that HCE possessed significantly higher calories and contents of valine and total phenols than CE; it also contained significant amounts of ferulic acid, sesamin, and sesamolin. HCE significantly decreased MDA and NO levels in serum and liver and increased liver GSH levels in the D-Gal-induced mice. HCE greatly enhanced SOD and CAT activities in serum and liver, and liver GPx activity, as well as upregulating SIRT1 expression and downregulating TNF-α, IL-1β, IL-6, iNOS, Cox-2, and MCP-1 expression in liver tissues. This study demonstrates that HCE was effective in suppressing the aging process through enhancing antioxidant and anti-inflammatory activities and modulating the aging-related gene expression.
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spelling pubmed-95134492022-09-28 Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice Wu, Shu-Jing Tung, Yi-Jou Yen, Ming-Hong Ng, Lean-Teik Front Nutr Nutrition This study aimed to examine the chemical and anti-aging properties of chicken essence (CE) prepared with Sesamum indicum, Angelica acutiloba, and Zingiber officinale (HCE). HCE was analyzed for nutritional and phytochemical composition, and its anti-aging effects were investigated on the D-galactose (Gal)-induced aging mice. Results showed that HCE possessed significantly higher calories and contents of valine and total phenols than CE; it also contained significant amounts of ferulic acid, sesamin, and sesamolin. HCE significantly decreased MDA and NO levels in serum and liver and increased liver GSH levels in the D-Gal-induced mice. HCE greatly enhanced SOD and CAT activities in serum and liver, and liver GPx activity, as well as upregulating SIRT1 expression and downregulating TNF-α, IL-1β, IL-6, iNOS, Cox-2, and MCP-1 expression in liver tissues. This study demonstrates that HCE was effective in suppressing the aging process through enhancing antioxidant and anti-inflammatory activities and modulating the aging-related gene expression. Frontiers Media S.A. 2022-09-13 /pmc/articles/PMC9513449/ /pubmed/36176640 http://dx.doi.org/10.3389/fnut.2022.989067 Text en Copyright © 2022 Wu, Tung, Yen and Ng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Wu, Shu-Jing
Tung, Yi-Jou
Yen, Ming-Hong
Ng, Lean-Teik
Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice
title Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice
title_full Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice
title_fullStr Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice
title_full_unstemmed Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice
title_short Chemical composition and anti-aging effects of standardized herbal chicken essence on D-galactose- induced senescent mice
title_sort chemical composition and anti-aging effects of standardized herbal chicken essence on d-galactose- induced senescent mice
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513449/
https://www.ncbi.nlm.nih.gov/pubmed/36176640
http://dx.doi.org/10.3389/fnut.2022.989067
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