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Cytochrome C as a potential clinical marker for diagnosis and treatment of glioma

Gliomas are the most prevalent kind of malignant and severe brain cancer. Apoptosis regulating mechanisms are disturbed in malignant gliomas, as they are in added forms of malignancy. Understanding apoptosis and other associated processes are thought to be critical for understanding the origins of m...

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Autores principales: Rana, Rashmi, Huirem, Rohit Singh, Kant, Ravi, Chauhan, Kirti, Sharma, Swati, Yashavarddhan, M. H., Chhabra, Satnam Singh, Acharya, Rajesh, Kalra, Samir Kumar, Gupta, Anshul, Jain, Sunila, Ganguly, Nirmal Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513483/
https://www.ncbi.nlm.nih.gov/pubmed/36176404
http://dx.doi.org/10.3389/fonc.2022.960787
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author Rana, Rashmi
Huirem, Rohit Singh
Kant, Ravi
Chauhan, Kirti
Sharma, Swati
Yashavarddhan, M. H.
Chhabra, Satnam Singh
Acharya, Rajesh
Kalra, Samir Kumar
Gupta, Anshul
Jain, Sunila
Ganguly, Nirmal Kumar
author_facet Rana, Rashmi
Huirem, Rohit Singh
Kant, Ravi
Chauhan, Kirti
Sharma, Swati
Yashavarddhan, M. H.
Chhabra, Satnam Singh
Acharya, Rajesh
Kalra, Samir Kumar
Gupta, Anshul
Jain, Sunila
Ganguly, Nirmal Kumar
author_sort Rana, Rashmi
collection PubMed
description Gliomas are the most prevalent kind of malignant and severe brain cancer. Apoptosis regulating mechanisms are disturbed in malignant gliomas, as they are in added forms of malignancy. Understanding apoptosis and other associated processes are thought to be critical for understanding the origins of malignant tumors and designing anti-cancerous drugs for the treatment. The purpose of this study was to evaluate the variation in the expression level of several apoptotic proteins that are responsible for apoptosis in low to high-grade glioma. This suggests a significant change in the expression of five apoptotic proteins: Clusterin, HSP27, Catalase, Cytochrome C, and SMAC. Cytochrome C, one of the five substantially altered proteins, is a crucial component of the apoptotic cascade. The complex enzyme Cytochrome C is involved in metabolic pathways such as respiration and cell death. The results demonstrated that Cytochrome C expression levels are lower in glioma tissues than in normal tissues. What’s more intriguing is that the expression level decreases with an increase in glioma grades. As a result, the discovery shows that Cytochrome C may be a target for glioma prognostic biomarkers.
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spelling pubmed-95134832022-09-28 Cytochrome C as a potential clinical marker for diagnosis and treatment of glioma Rana, Rashmi Huirem, Rohit Singh Kant, Ravi Chauhan, Kirti Sharma, Swati Yashavarddhan, M. H. Chhabra, Satnam Singh Acharya, Rajesh Kalra, Samir Kumar Gupta, Anshul Jain, Sunila Ganguly, Nirmal Kumar Front Oncol Oncology Gliomas are the most prevalent kind of malignant and severe brain cancer. Apoptosis regulating mechanisms are disturbed in malignant gliomas, as they are in added forms of malignancy. Understanding apoptosis and other associated processes are thought to be critical for understanding the origins of malignant tumors and designing anti-cancerous drugs for the treatment. The purpose of this study was to evaluate the variation in the expression level of several apoptotic proteins that are responsible for apoptosis in low to high-grade glioma. This suggests a significant change in the expression of five apoptotic proteins: Clusterin, HSP27, Catalase, Cytochrome C, and SMAC. Cytochrome C, one of the five substantially altered proteins, is a crucial component of the apoptotic cascade. The complex enzyme Cytochrome C is involved in metabolic pathways such as respiration and cell death. The results demonstrated that Cytochrome C expression levels are lower in glioma tissues than in normal tissues. What’s more intriguing is that the expression level decreases with an increase in glioma grades. As a result, the discovery shows that Cytochrome C may be a target for glioma prognostic biomarkers. Frontiers Media S.A. 2022-09-13 /pmc/articles/PMC9513483/ /pubmed/36176404 http://dx.doi.org/10.3389/fonc.2022.960787 Text en Copyright © 2022 Rana, Huirem, Kant, Chauhan, Sharma, Yashavarddhan, Chhabra, Acharya, Kalra, Gupta, Jain and Ganguly https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Rana, Rashmi
Huirem, Rohit Singh
Kant, Ravi
Chauhan, Kirti
Sharma, Swati
Yashavarddhan, M. H.
Chhabra, Satnam Singh
Acharya, Rajesh
Kalra, Samir Kumar
Gupta, Anshul
Jain, Sunila
Ganguly, Nirmal Kumar
Cytochrome C as a potential clinical marker for diagnosis and treatment of glioma
title Cytochrome C as a potential clinical marker for diagnosis and treatment of glioma
title_full Cytochrome C as a potential clinical marker for diagnosis and treatment of glioma
title_fullStr Cytochrome C as a potential clinical marker for diagnosis and treatment of glioma
title_full_unstemmed Cytochrome C as a potential clinical marker for diagnosis and treatment of glioma
title_short Cytochrome C as a potential clinical marker for diagnosis and treatment of glioma
title_sort cytochrome c as a potential clinical marker for diagnosis and treatment of glioma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513483/
https://www.ncbi.nlm.nih.gov/pubmed/36176404
http://dx.doi.org/10.3389/fonc.2022.960787
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