Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis

Senescence of activated hepatic stellate cells (aHSCs) is a stable growth arrest that is implicated in liver fibrosis regression. Senescent cells often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). But little is known about how alanine-serine-cysteine transporter t...

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Detalles Bibliográficos
Autores principales: Wang, Feixia, Li, Zhanghao, Chen, Li, Yang, Ting, Liang, Baoyu, Zhang, Zili, Shao, Jiangjuan, Xu, Xuefen, Yin, Guoping, Wang, Shijun, Ding, Hai, Zhang, Feng, Zheng, Shizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513497/
https://www.ncbi.nlm.nih.gov/pubmed/36176909
http://dx.doi.org/10.1016/j.apsb.2022.03.014

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