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Liver cancer concurrent with chronic myelocytic leukemia and extreme thrombocytosis: a rare case report

Chronic myelocytic leukemia (CML) can occasionally occur after long-term chemotherapy for solid tumors; solid tumors secondary to chemotherapy and biotherapy for CML have also been reported. However, concurrence of these two phenomena in an untreated patient has seldom been reported. Herein, we desc...

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Autores principales: Han, Ping, Han, Zhi-Qiang, Mao, Xia, Wang, Jin, Li, Qin-Lu, Xiao, Min, Meng, Li, Tian, De-An, Hong, Zhen-Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513580/
https://www.ncbi.nlm.nih.gov/pubmed/36151757
http://dx.doi.org/10.1177/03000605221123684
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author Han, Ping
Han, Zhi-Qiang
Mao, Xia
Wang, Jin
Li, Qin-Lu
Xiao, Min
Meng, Li
Tian, De-An
Hong, Zhen-Ya
author_facet Han, Ping
Han, Zhi-Qiang
Mao, Xia
Wang, Jin
Li, Qin-Lu
Xiao, Min
Meng, Li
Tian, De-An
Hong, Zhen-Ya
author_sort Han, Ping
collection PubMed
description Chronic myelocytic leukemia (CML) can occasionally occur after long-term chemotherapy for solid tumors; solid tumors secondary to chemotherapy and biotherapy for CML have also been reported. However, concurrence of these two phenomena in an untreated patient has seldom been reported. Herein, we describe the case of a female patient in her early 60 s who was transferred to the liver surgery department after the discovery of a large liver mass and elevated plasma alpha-fetoprotein levels. She was initially diagnosed with liver cancer. Blood tests indicated an increased platelet count (2464 × 10(9)/L). Chromosomal examination from a bone marrow biopsy indicated the presence of the t(9;22) translocation, and subsequent fluorescence in situ hybridization and PCR were positive for the BCR-ABL rearrangement. A diagnosis of CML was made. The patient received hydroxyurea and imatinib to treat CML and underwent subsequent platelet-lowering therapy and a liver biopsy, which suggested moderately poorly differentiated adenocarcinoma or potentially hepatic metastatic carcinoma. However, the patient refused further pathological examination or screening for the site of the primary tumor. She died 6.5 months after discharge. The exact relationship between the two tumors remains unclear, and more patients need to be evaluated.
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spelling pubmed-95135802022-09-28 Liver cancer concurrent with chronic myelocytic leukemia and extreme thrombocytosis: a rare case report Han, Ping Han, Zhi-Qiang Mao, Xia Wang, Jin Li, Qin-Lu Xiao, Min Meng, Li Tian, De-An Hong, Zhen-Ya J Int Med Res Case Reports Chronic myelocytic leukemia (CML) can occasionally occur after long-term chemotherapy for solid tumors; solid tumors secondary to chemotherapy and biotherapy for CML have also been reported. However, concurrence of these two phenomena in an untreated patient has seldom been reported. Herein, we describe the case of a female patient in her early 60 s who was transferred to the liver surgery department after the discovery of a large liver mass and elevated plasma alpha-fetoprotein levels. She was initially diagnosed with liver cancer. Blood tests indicated an increased platelet count (2464 × 10(9)/L). Chromosomal examination from a bone marrow biopsy indicated the presence of the t(9;22) translocation, and subsequent fluorescence in situ hybridization and PCR were positive for the BCR-ABL rearrangement. A diagnosis of CML was made. The patient received hydroxyurea and imatinib to treat CML and underwent subsequent platelet-lowering therapy and a liver biopsy, which suggested moderately poorly differentiated adenocarcinoma or potentially hepatic metastatic carcinoma. However, the patient refused further pathological examination or screening for the site of the primary tumor. She died 6.5 months after discharge. The exact relationship between the two tumors remains unclear, and more patients need to be evaluated. SAGE Publications 2022-09-23 /pmc/articles/PMC9513580/ /pubmed/36151757 http://dx.doi.org/10.1177/03000605221123684 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Han, Ping
Han, Zhi-Qiang
Mao, Xia
Wang, Jin
Li, Qin-Lu
Xiao, Min
Meng, Li
Tian, De-An
Hong, Zhen-Ya
Liver cancer concurrent with chronic myelocytic leukemia and extreme thrombocytosis: a rare case report
title Liver cancer concurrent with chronic myelocytic leukemia and extreme thrombocytosis: a rare case report
title_full Liver cancer concurrent with chronic myelocytic leukemia and extreme thrombocytosis: a rare case report
title_fullStr Liver cancer concurrent with chronic myelocytic leukemia and extreme thrombocytosis: a rare case report
title_full_unstemmed Liver cancer concurrent with chronic myelocytic leukemia and extreme thrombocytosis: a rare case report
title_short Liver cancer concurrent with chronic myelocytic leukemia and extreme thrombocytosis: a rare case report
title_sort liver cancer concurrent with chronic myelocytic leukemia and extreme thrombocytosis: a rare case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513580/
https://www.ncbi.nlm.nih.gov/pubmed/36151757
http://dx.doi.org/10.1177/03000605221123684
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