Intradiscal injection of human recombinant BMP-4 does not reverse intervertebral disc degeneration induced by nuclectomy in sheep

BACKGROUND: Intervertebral disc (IVD) degeneration is suggested as a major cause of chronic low back pain (LBP). Intradiscal delivery of growth factors has been proposed as a promising strategy for IVD repair and regeneration. Previously, BMP-4 was shown to be more potent in promoting extracellular...

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Detalles Bibliográficos
Autores principales: Du, Jie, Garcia, João P., Bach, Frances C., Tellegen, Anna R., Grad, Sibylle, Li, Zhen, Castelein, René M., Meij, Björn P., Tryfonidou, Marianna A., Creemers, Laura B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513727/
https://www.ncbi.nlm.nih.gov/pubmed/36196149
http://dx.doi.org/10.1016/j.jot.2022.08.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513727/
https://www.ncbi.nlm.nih.gov/pubmed/36196149
http://dx.doi.org/10.1016/j.jot.2022.08.006

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