Oncolytic virus-mediated p53 overexpression promotes immunogenic cell death and efficacy of PD-1 blockade in pancreatic cancer

Immune checkpoint inhibitors, including anti-programmed cell death 1 (PD-1) antibody, provide improved clinical outcome in certain cancers. However, pancreatic ductal adenocarcinoma (PDAC) is refractory to PD-1 blockade therapy due to poor immune response. Oncolytic virotherapy is a novel approach f...

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Detalles Bibliográficos
Autores principales: Araki, Hiroyuki, Tazawa, Hiroshi, Kanaya, Nobuhiko, Kajiwara, Yoshinori, Yamada, Motohiko, Hashimoto, Masashi, Kikuchi, Satoru, Kuroda, Shinji, Yoshida, Ryuichi, Umeda, Yuzo, Urata, Yasuo, Kagawa, Shunsuke, Fujiwara, Toshiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513735/
https://www.ncbi.nlm.nih.gov/pubmed/36212775
http://dx.doi.org/10.1016/j.omto.2022.09.003

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