Interleukin 22 and its association with neurodegenerative disease activity

It is worth noting that neuroinflammation is well recognized as a symptom of neurodegenerative diseases (NDs). The regulation of neuroinflammation becomes an attractive focus for innovative ND treatment technologies. There is evidence that IL-22 is associated with the development and progression of...

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Autores principales: Chen, Wenjian, Wang, Jianpeng, Yang, Huaizhi, Sun, Yuankai, Chen, Bangjie, Liu, Yuchen, Han, Yanxun, Shan, Ming, Zhan, Junfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514046/
https://www.ncbi.nlm.nih.gov/pubmed/36176437
http://dx.doi.org/10.3389/fphar.2022.958022
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author Chen, Wenjian
Wang, Jianpeng
Yang, Huaizhi
Sun, Yuankai
Chen, Bangjie
Liu, Yuchen
Han, Yanxun
Shan, Ming
Zhan, Junfeng
author_facet Chen, Wenjian
Wang, Jianpeng
Yang, Huaizhi
Sun, Yuankai
Chen, Bangjie
Liu, Yuchen
Han, Yanxun
Shan, Ming
Zhan, Junfeng
author_sort Chen, Wenjian
collection PubMed
description It is worth noting that neuroinflammation is well recognized as a symptom of neurodegenerative diseases (NDs). The regulation of neuroinflammation becomes an attractive focus for innovative ND treatment technologies. There is evidence that IL-22 is associated with the development and progression of a wide assortment of NDs. For example, IL-22 can activate glial cells, causing them to generate pro-inflammatory cytokines and encourage lymphocyte infiltration in the brain. IL-22 mRNA is highly expressed in Alzheimer’s disease (AD) patients, and a high expression of IL-22 has also been detected in the brains of patients with other NDs. We examine the role of IL-22 in the development and treatment of NDs in this review, and we believe that IL-22 has therapeutic potential in these diseases.
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spelling pubmed-95140462022-09-28 Interleukin 22 and its association with neurodegenerative disease activity Chen, Wenjian Wang, Jianpeng Yang, Huaizhi Sun, Yuankai Chen, Bangjie Liu, Yuchen Han, Yanxun Shan, Ming Zhan, Junfeng Front Pharmacol Pharmacology It is worth noting that neuroinflammation is well recognized as a symptom of neurodegenerative diseases (NDs). The regulation of neuroinflammation becomes an attractive focus for innovative ND treatment technologies. There is evidence that IL-22 is associated with the development and progression of a wide assortment of NDs. For example, IL-22 can activate glial cells, causing them to generate pro-inflammatory cytokines and encourage lymphocyte infiltration in the brain. IL-22 mRNA is highly expressed in Alzheimer’s disease (AD) patients, and a high expression of IL-22 has also been detected in the brains of patients with other NDs. We examine the role of IL-22 in the development and treatment of NDs in this review, and we believe that IL-22 has therapeutic potential in these diseases. Frontiers Media S.A. 2022-09-13 /pmc/articles/PMC9514046/ /pubmed/36176437 http://dx.doi.org/10.3389/fphar.2022.958022 Text en Copyright © 2022 Chen, Wang, Yang, Sun, Chen, Liu, Han, Shan and Zhan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Wenjian
Wang, Jianpeng
Yang, Huaizhi
Sun, Yuankai
Chen, Bangjie
Liu, Yuchen
Han, Yanxun
Shan, Ming
Zhan, Junfeng
Interleukin 22 and its association with neurodegenerative disease activity
title Interleukin 22 and its association with neurodegenerative disease activity
title_full Interleukin 22 and its association with neurodegenerative disease activity
title_fullStr Interleukin 22 and its association with neurodegenerative disease activity
title_full_unstemmed Interleukin 22 and its association with neurodegenerative disease activity
title_short Interleukin 22 and its association with neurodegenerative disease activity
title_sort interleukin 22 and its association with neurodegenerative disease activity
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514046/
https://www.ncbi.nlm.nih.gov/pubmed/36176437
http://dx.doi.org/10.3389/fphar.2022.958022
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