Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections

Lassa fever is a viral hemorrhagic fever treated with supportive care and the broad-spectrum antiviral drug ribavirin. The pathophysiology, especially the role of hyperinflammation, of this disease is unknown. We report successful remission of complicated Lassa fever in 2 patients in Nigeria who rec...

Descripción completa

Detalles Bibliográficos
Autores principales: Okogbenin, Sylvanus, Erameh, Cyril, Okoeguale, Joseph, Edeawe, Osahogie, Ekuaze, Esele, Iraoyah, Kelly, Agho, John, Groger, Mirjam, Kreuels, Benno, Oestereich, Lisa, Babatunde, Femi O., Akhideno, Peter, Günther, Stephan, Ramharter, Michael, Omansen, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514364/
https://www.ncbi.nlm.nih.gov/pubmed/36148915
http://dx.doi.org/10.3201/eid2810.220625
_version_ 1784798258936152064
author Okogbenin, Sylvanus
Erameh, Cyril
Okoeguale, Joseph
Edeawe, Osahogie
Ekuaze, Esele
Iraoyah, Kelly
Agho, John
Groger, Mirjam
Kreuels, Benno
Oestereich, Lisa
Babatunde, Femi O.
Akhideno, Peter
Günther, Stephan
Ramharter, Michael
Omansen, Till
author_facet Okogbenin, Sylvanus
Erameh, Cyril
Okoeguale, Joseph
Edeawe, Osahogie
Ekuaze, Esele
Iraoyah, Kelly
Agho, John
Groger, Mirjam
Kreuels, Benno
Oestereich, Lisa
Babatunde, Femi O.
Akhideno, Peter
Günther, Stephan
Ramharter, Michael
Omansen, Till
author_sort Okogbenin, Sylvanus
collection PubMed
description Lassa fever is a viral hemorrhagic fever treated with supportive care and the broad-spectrum antiviral drug ribavirin. The pathophysiology, especially the role of hyperinflammation, of this disease is unknown. We report successful remission of complicated Lassa fever in 2 patients in Nigeria who received the antiinflammatory agent dexamethasone and standard ribavirin.
format Online
Article
Text
id pubmed-9514364
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-95143642022-10-01 Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections Okogbenin, Sylvanus Erameh, Cyril Okoeguale, Joseph Edeawe, Osahogie Ekuaze, Esele Iraoyah, Kelly Agho, John Groger, Mirjam Kreuels, Benno Oestereich, Lisa Babatunde, Femi O. Akhideno, Peter Günther, Stephan Ramharter, Michael Omansen, Till Emerg Infect Dis Dispatch Lassa fever is a viral hemorrhagic fever treated with supportive care and the broad-spectrum antiviral drug ribavirin. The pathophysiology, especially the role of hyperinflammation, of this disease is unknown. We report successful remission of complicated Lassa fever in 2 patients in Nigeria who received the antiinflammatory agent dexamethasone and standard ribavirin. Centers for Disease Control and Prevention 2022-10 /pmc/articles/PMC9514364/ /pubmed/36148915 http://dx.doi.org/10.3201/eid2810.220625 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Okogbenin, Sylvanus
Erameh, Cyril
Okoeguale, Joseph
Edeawe, Osahogie
Ekuaze, Esele
Iraoyah, Kelly
Agho, John
Groger, Mirjam
Kreuels, Benno
Oestereich, Lisa
Babatunde, Femi O.
Akhideno, Peter
Günther, Stephan
Ramharter, Michael
Omansen, Till
Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections
title Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections
title_full Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections
title_fullStr Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections
title_full_unstemmed Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections
title_short Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections
title_sort two cases of lassa fever successfully treated with ribavirin and adjunct dexamethasone for concomitant infections
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514364/
https://www.ncbi.nlm.nih.gov/pubmed/36148915
http://dx.doi.org/10.3201/eid2810.220625
work_keys_str_mv AT okogbeninsylvanus twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT eramehcyril twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT okoegualejoseph twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT edeaweosahogie twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT ekuazeesele twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT iraoyahkelly twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT aghojohn twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT grogermirjam twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT kreuelsbenno twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT oestereichlisa twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT babatundefemio twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT akhidenopeter twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT guntherstephan twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT ramhartermichael twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections
AT omansentill twocasesoflassafeversuccessfullytreatedwithribavirinandadjunctdexamethasoneforconcomitantinfections

Ejemplares similares