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Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach

Alzheimer’s disease and related dementias (ADRD) is two times more prevalent among compared to non-Hispanic Whites. Despite the higher prevalence of ADRD among older African Americans, recent estimates suggest research enrollment by those who identify as African American remains limited. The purpose...

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Autores principales: Shaw, A. R., Perales-Puchalt, J., Moore, T., Weatherspoon, P., Robinson, M., Hill, C. V., Vidoni, Eric D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514712/
https://www.ncbi.nlm.nih.gov/pubmed/36281671
http://dx.doi.org/10.14283/jpad.2022.82
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author Shaw, A. R.
Perales-Puchalt, J.
Moore, T.
Weatherspoon, P.
Robinson, M.
Hill, C. V.
Vidoni, Eric D.
author_facet Shaw, A. R.
Perales-Puchalt, J.
Moore, T.
Weatherspoon, P.
Robinson, M.
Hill, C. V.
Vidoni, Eric D.
author_sort Shaw, A. R.
collection PubMed
description Alzheimer’s disease and related dementias (ADRD) is two times more prevalent among compared to non-Hispanic Whites. Despite the higher prevalence of ADRD among older African Americans, recent estimates suggest research enrollment by those who identify as African American remains limited. The purpose of the study is to 1) explore how a culturally tailored community education program impacts clinical trial interest and enrollment in ADRD research studies and to 2) identify how applicable the African American community perceived the culturally tailored curriculum. Using a community-engaged research approach, we collaborated with predominately African American serving community-based organizations to support content development and delivery of Aging with Grace (AWG), a culturally tailored ADRD educational curriculum. A total of five AWG presentations were given to 66 attendees. Most attendees (67%) expressed interest in participating in clinical trials after attending AWG. Enrollment increased within an observational study (84%) and lifestyle prevention clinical trials (52%) from 2018 to 2019. Attendees (32%) also perceived an increase in ADRD knowledge from attending AWG and 89.1% believed more African Americans should participate in research. Our work demonstrates the effectiveness of a culturally tailored community education program to enhance knowledge, clinical trial interest, and recruitment into observational studies and lifestyle ADRD clinical trials among older African Americans. Education programs developed in partnership with the community can serve as bridge to research participation for underrepresented minorities in clinical research. Future studies should assess long-term retention of knowledge and research readiness.
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spelling pubmed-95147122022-09-28 Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach Shaw, A. R. Perales-Puchalt, J. Moore, T. Weatherspoon, P. Robinson, M. Hill, C. V. Vidoni, Eric D. J Prev Alzheimers Dis Original Research Alzheimer’s disease and related dementias (ADRD) is two times more prevalent among compared to non-Hispanic Whites. Despite the higher prevalence of ADRD among older African Americans, recent estimates suggest research enrollment by those who identify as African American remains limited. The purpose of the study is to 1) explore how a culturally tailored community education program impacts clinical trial interest and enrollment in ADRD research studies and to 2) identify how applicable the African American community perceived the culturally tailored curriculum. Using a community-engaged research approach, we collaborated with predominately African American serving community-based organizations to support content development and delivery of Aging with Grace (AWG), a culturally tailored ADRD educational curriculum. A total of five AWG presentations were given to 66 attendees. Most attendees (67%) expressed interest in participating in clinical trials after attending AWG. Enrollment increased within an observational study (84%) and lifestyle prevention clinical trials (52%) from 2018 to 2019. Attendees (32%) also perceived an increase in ADRD knowledge from attending AWG and 89.1% believed more African Americans should participate in research. Our work demonstrates the effectiveness of a culturally tailored community education program to enhance knowledge, clinical trial interest, and recruitment into observational studies and lifestyle ADRD clinical trials among older African Americans. Education programs developed in partnership with the community can serve as bridge to research participation for underrepresented minorities in clinical research. Future studies should assess long-term retention of knowledge and research readiness. Springer International Publishing 2022-09-27 2022 /pmc/articles/PMC9514712/ /pubmed/36281671 http://dx.doi.org/10.14283/jpad.2022.82 Text en © Serdi 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Research
Shaw, A. R.
Perales-Puchalt, J.
Moore, T.
Weatherspoon, P.
Robinson, M.
Hill, C. V.
Vidoni, Eric D.
Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach
title Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach
title_full Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach
title_fullStr Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach
title_full_unstemmed Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach
title_short Recruitment of Older African Americans in Alzheimer’s Disease Clinical Trials Using a Community Education Approach
title_sort recruitment of older african americans in alzheimer’s disease clinical trials using a community education approach
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514712/
https://www.ncbi.nlm.nih.gov/pubmed/36281671
http://dx.doi.org/10.14283/jpad.2022.82
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