Cargando…
Fidaxomicin Use in the Pediatric Population with Clostridioides difficile
Clostridioides difficile infection (CDI) remains a devastating infection both in hospital settings and in the community. While a number of antibiotics have anti-C. difficile activity, fidaxomicin is unique as a minimally absorbed antibiotic with narrow spectrum of activity. These features make it an...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514785/ https://www.ncbi.nlm.nih.gov/pubmed/36177387 http://dx.doi.org/10.2147/CPAA.S273318 |
_version_ | 1784798345205645312 |
---|---|
author | Oliver, Meredith B Vaughn, Byron P |
author_facet | Oliver, Meredith B Vaughn, Byron P |
author_sort | Oliver, Meredith B |
collection | PubMed |
description | Clostridioides difficile infection (CDI) remains a devastating infection both in hospital settings and in the community. While a number of antibiotics have anti-C. difficile activity, fidaxomicin is unique as a minimally absorbed antibiotic with narrow spectrum of activity. These features make it an appealing option for pediatric CDI to balance safety and efficacy. The purpose of this structured review was to outline the clinical evidence for safety and efficacy of fidaxomicin for pediatric CDI. A structured literature search was performed to identify relevant clinical data. Fidaxomicin is similarly effective to oral vancomycin with a lower rate of recurrent CDI. There were no serious safety signals reported with fidaxomicin. In conclusion, fidaxomicin is a safe and effective treatment option for pediatric CDI. |
format | Online Article Text |
id | pubmed-9514785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-95147852022-09-28 Fidaxomicin Use in the Pediatric Population with Clostridioides difficile Oliver, Meredith B Vaughn, Byron P Clin Pharmacol Review Clostridioides difficile infection (CDI) remains a devastating infection both in hospital settings and in the community. While a number of antibiotics have anti-C. difficile activity, fidaxomicin is unique as a minimally absorbed antibiotic with narrow spectrum of activity. These features make it an appealing option for pediatric CDI to balance safety and efficacy. The purpose of this structured review was to outline the clinical evidence for safety and efficacy of fidaxomicin for pediatric CDI. A structured literature search was performed to identify relevant clinical data. Fidaxomicin is similarly effective to oral vancomycin with a lower rate of recurrent CDI. There were no serious safety signals reported with fidaxomicin. In conclusion, fidaxomicin is a safe and effective treatment option for pediatric CDI. Dove 2022-09-23 /pmc/articles/PMC9514785/ /pubmed/36177387 http://dx.doi.org/10.2147/CPAA.S273318 Text en © 2022 Oliver and Vaughn. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Oliver, Meredith B Vaughn, Byron P Fidaxomicin Use in the Pediatric Population with Clostridioides difficile |
title | Fidaxomicin Use in the Pediatric Population with Clostridioides difficile |
title_full | Fidaxomicin Use in the Pediatric Population with Clostridioides difficile |
title_fullStr | Fidaxomicin Use in the Pediatric Population with Clostridioides difficile |
title_full_unstemmed | Fidaxomicin Use in the Pediatric Population with Clostridioides difficile |
title_short | Fidaxomicin Use in the Pediatric Population with Clostridioides difficile |
title_sort | fidaxomicin use in the pediatric population with clostridioides difficile |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514785/ https://www.ncbi.nlm.nih.gov/pubmed/36177387 http://dx.doi.org/10.2147/CPAA.S273318 |
work_keys_str_mv | AT olivermeredithb fidaxomicinuseinthepediatricpopulationwithclostridioidesdifficile AT vaughnbyronp fidaxomicinuseinthepediatricpopulationwithclostridioidesdifficile |