Cargando…

The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles

Sharks and other cartilaginous fish produce new antigen receptor (IgNAR) antibodies, as key part of their humoral immune response and are the phylogenetically oldest living organisms that possess an immunoglobulin (Ig)-based adaptive immune system. IgNAR antibodies are naturally occurring heavy-chai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernández-Quintero, Monica L., Fischer, Anna-Lena M., Kokot, Janik, Waibl, Franz, Seidler, Clarissa A., Liedl, Klaus R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514858/ https://www.ncbi.nlm.nih.gov/pubmed/36177031 http://dx.doi.org/10.3389/fimmu.2022.953917

Ejemplares similares

Shark Antibody Variable Domains Rigidify Upon Affinity Maturation—Understanding the Potential of Shark Immunoglobulins as Therapeutics
por: Fernández-Quintero, Monica L., et al.
Publicado: (2021)

Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody
por: Cheong, Wei Shien, et al.
Publicado: (2020)

Structural Characterization of Nanobodies during Germline Maturation
por: Seidler, Clarissa A., et al.
Publicado: (2023)

T-Cell Receptor Variable β Domains Rigidify During Affinity Maturation
por: Fernández-Quintero, Monica L., et al.
Publicado: (2020)

Addressing Challenges of Macrocyclic Conformational Sampling in Polar and Apolar Solvents: Lessons for Chameleonicity
por: Tang, Xuechen, et al.
Publicado: (2023)

Challenges in antibody structure prediction
por: Fernández-Quintero, Monica L., et al.
Publicado: (2023)

Unleashing the power of shark variable single domains (VNARs): broadly neutralizing tools for combating SARS-CoV-2
por: Cabanillas-Bernal, Olivia, et al.
Publicado: (2023)

Synthetic libraries of shark vNAR domains with different cysteine numbers within the CDR3
por: Cabanillas-Bernal, Olivia, et al.
Publicado: (2019)

Conformational Ensembles of Antibodies Determine Their Hydrophobicity
por: Waibl, Franz, et al.
Publicado: (2021)

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development
por: Steven, John, et al.
Publicado: (2017)

Local and Global Rigidification Upon Antibody Affinity Maturation
por: Fernández-Quintero, Monica L., et al.
Publicado: (2020)

Therapeutic Potential of Shark Anti-ICOSL VNAR Domains is Exemplified in a Murine Model of Autoimmune Non-Infectious Uveitis
por: Kovaleva, Marina, et al.
Publicado: (2017)

Isolation and Characterization of Targeting-HBsAg VNAR Single Domain Antibodies from Whitespotted Bamboo Sharks (Chiloscyllium plagiosum)
por: Jiang, Xierui, et al.
Publicado: (2023)

pH-dependent structural diversity of profilin allergens determines thermal stability
por: Hofer, Florian, et al.
Publicado: (2022)

Screening and Characterization of Shark-Derived VNARs against SARS-CoV-2 Spike RBD Protein
por: Chen, Yu-Lei, et al.
Publicado: (2022)

Structural mechanism of Fab domain dissociation as a measure of interface stability
por: Pomarici, Nancy D., et al.
Publicado: (2023)

Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR
por: Pothin, Elodie, et al.
Publicado: (2020)

T-Cell Receptor CDR3 Loop Conformations in Solution Shift the Relative Vα-Vβ Domain Distributions
por: Fernández-Quintero, Monica L., et al.
Publicado: (2020)

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain
por: Burgess, Selena G., et al.
Publicado: (2016)

Explicit solvation thermodynamics in ionic solution: extending grid inhomogeneous solvation theory to solvation free energy of salt–water mixtures
por: Waibl, Franz, et al.
Publicado: (2022)

Antibodies exhibit multiple paratope states influencing V(H)–V(L) domain orientations
por: Fernández-Quintero, Monica L., et al.
Publicado: (2020)

CDR-H3 loop ensemble in solution – conformational selection upon antibody binding
por: Fernández-Quintero, Monica L., et al.
Publicado: (2019)

Comparison of hydrophobicity scales for predicting biophysical properties of antibodies
por: Waibl, Franz, et al.
Publicado: (2022)

Evolution of the Immunoglobulin Isotypes—Variations of Biophysical Properties among Animal Classes
por: Pomarici, Nancy D., et al.
Publicado: (2023)

Conformational selection of allergen-antibody complexes—surface plasticity of paratopes and epitopes
por: Fernández-Quintero, Monica L, et al.
Publicado: (2019)

Protein-Protein Binding as a Two-Step Mechanism: Preselection of Encounter Poses during the Binding of BPTI and Trypsin
por: Kahler, Ursula, et al.
Publicado: (2020)

Solvation Free Energy as a Measure of Hydrophobicity: Application to Serine Protease Binding Interfaces
por: Kraml, Johannes, et al.
Publicado: (2019)

Antibody humanization—the Influence of the antibody framework on the CDR-H3 loop ensemble in solution
por: Fernández-Quintero, Monica L, et al.
Publicado: (2019)

Identification of Anti-TNFα VNAR Single Domain Antibodies from Whitespotted Bambooshark (Chiloscyllium plagiosum)
por: Zhao, Linfei, et al.
Publicado: (2022)

Ensembles in solution as a new paradigm for antibody structure prediction and design
por: Fernández-Quintero, Monica L., et al.
Publicado: (2021)

Characterizing the Diversity of the CDR-H3 Loop Conformational Ensembles in Relationship to Antibody Binding Properties
por: Fernández-Quintero, Monica L., et al.
Publicado: (2019)

Conformational Shifts of Stacked Heteroaromatics: Vacuum vs. Water Studied by Machine Learning
por: Loeffler, Johannes R., et al.
Publicado: (2021)

Bispecific antibodies—effects of point mutations on C(H)3-C(H)3 interface stability
por: Pomarici, Nancy D, et al.
Publicado: (2022)

VNAR development through antigen immunization of Japanese topeshark (Hemitriakis japanica)
por: Takeda, Hiroyuki, et al.
Publicado: (2023)

Neutralizing Ability of a Single Domain VNAR Antibody: In Vitro Neutralization of SARS-CoV-2 Variants of Concern
por: Valdovino-Navarro, Blanca J., et al.
Publicado: (2022)

Nanobody Paratope Ensembles in Solution Characterized by MD Simulations and NMR
por: Fernández-Quintero, Monica L., et al.
Publicado: (2022)

Balance between hydration enthalpy and entropy is important for ice binding surfaces in Antifreeze Proteins
por: Schauperl, Michael, et al.
Publicado: (2017)

Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments
por: Fernández-Quintero, Monica L., et al.
Publicado: (2020)

Intraocular Penetration of a vNAR: In Vivo and In Vitro VEGF(165) Neutralization
por: Camacho-Villegas, Tanya A., et al.
Publicado: (2018)

Antibody CDR loops as ensembles in solution vs. canonical clusters from X-ray structures
por: Fernández-Quintero, Monica L., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dj1mjtsddg8uro0sflmotqp5d1