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The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles

Sharks and other cartilaginous fish produce new antigen receptor (IgNAR) antibodies, as key part of their humoral immune response and are the phylogenetically oldest living organisms that possess an immunoglobulin (Ig)-based adaptive immune system. IgNAR antibodies are naturally occurring heavy-chai...

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Detalles Bibliográficos
Autores principales:	Fernández-Quintero, Monica L., Fischer, Anna-Lena M., Kokot, Janik, Waibl, Franz, Seidler, Clarissa A., Liedl, Klaus R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514858/ https://www.ncbi.nlm.nih.gov/pubmed/36177031 http://dx.doi.org/10.3389/fimmu.2022.953917

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