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Effect of Inactivated SARS-CoV-2 Vaccines and ChAdOx1 nCoV-19 Vaccination to Prevent COVID-19 in Thai Households (VacPrevent trial)
OBJECTIVES: SARS-CoV-2 is primarily transmitted within households, with massive healthcare system burdens. The role of inactivated vaccines and ChAdOx1 nCoV-19 vaccination in the prevention of within-household transmission remains unknown. METHODS: This observational case-control study tracked 408 S...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514960/ https://www.ncbi.nlm.nih.gov/pubmed/36180032 http://dx.doi.org/10.1016/j.ijid.2022.09.032 |
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author | Muadchimkaew, Marisa Siripongboonsitti, Taweegrit Wongpatcharawarakul, Saowanee Boonsankaew, Chanyapak Tawinprai, Kriangkrai Soonklang, Kamonwan Mahanonda, Nithi |
author_facet | Muadchimkaew, Marisa Siripongboonsitti, Taweegrit Wongpatcharawarakul, Saowanee Boonsankaew, Chanyapak Tawinprai, Kriangkrai Soonklang, Kamonwan Mahanonda, Nithi |
author_sort | Muadchimkaew, Marisa |
collection | PubMed |
description | OBJECTIVES: SARS-CoV-2 is primarily transmitted within households, with massive healthcare system burdens. The role of inactivated vaccines and ChAdOx1 nCoV-19 vaccination in the prevention of within-household transmission remains unknown. METHODS: This observational case-control study tracked 408 SARS-CoV-2 polymerase chain reaction–confirmed index cases from April to September 2021. This study aimed to prove the benefit of inactivated and ChAdOx1 nCoV-19 vaccinated index cases in preventing within-household transmissibility. RESULTS: A total of 1178 household contacts were investigated. A total of 231 index cases were vaccinated with inactivated or ChAdOx1 nCoV-19 vaccine, and 177 were unvaccinated. The vaccinated index cases exhibited a 7.8% risk reduction in household transmission. There was no difference in the secondary attack rate of 50.77% in unvaccinated cases compared with 46.81% in vaccinated index cases (P-value = 0.177). Those who completed the two-dose SARS-CoV-2 vaccination demonstrated a 93% reduction in household transmissibility within 14-90 days. The effectiveness for preventing household transmission was 26.09%. The 87% reduced risk of household transmissibility was observed among those who wore masks. CONCLUSION: The completed two-dose SARS-CoV-2 inactivated and ChAdOx1 nCoV-19 vaccination within 14-90 days among index cases demonstrated benefits in preventing within-household transmissibility. Implementing high-efficacy vaccination and an appropriate booster dose can prevent household transmission. |
format | Online Article Text |
id | pubmed-9514960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95149602022-09-28 Effect of Inactivated SARS-CoV-2 Vaccines and ChAdOx1 nCoV-19 Vaccination to Prevent COVID-19 in Thai Households (VacPrevent trial) Muadchimkaew, Marisa Siripongboonsitti, Taweegrit Wongpatcharawarakul, Saowanee Boonsankaew, Chanyapak Tawinprai, Kriangkrai Soonklang, Kamonwan Mahanonda, Nithi Int J Infect Dis Article OBJECTIVES: SARS-CoV-2 is primarily transmitted within households, with massive healthcare system burdens. The role of inactivated vaccines and ChAdOx1 nCoV-19 vaccination in the prevention of within-household transmission remains unknown. METHODS: This observational case-control study tracked 408 SARS-CoV-2 polymerase chain reaction–confirmed index cases from April to September 2021. This study aimed to prove the benefit of inactivated and ChAdOx1 nCoV-19 vaccinated index cases in preventing within-household transmissibility. RESULTS: A total of 1178 household contacts were investigated. A total of 231 index cases were vaccinated with inactivated or ChAdOx1 nCoV-19 vaccine, and 177 were unvaccinated. The vaccinated index cases exhibited a 7.8% risk reduction in household transmission. There was no difference in the secondary attack rate of 50.77% in unvaccinated cases compared with 46.81% in vaccinated index cases (P-value = 0.177). Those who completed the two-dose SARS-CoV-2 vaccination demonstrated a 93% reduction in household transmissibility within 14-90 days. The effectiveness for preventing household transmission was 26.09%. The 87% reduced risk of household transmissibility was observed among those who wore masks. CONCLUSION: The completed two-dose SARS-CoV-2 inactivated and ChAdOx1 nCoV-19 vaccination within 14-90 days among index cases demonstrated benefits in preventing within-household transmissibility. Implementing high-efficacy vaccination and an appropriate booster dose can prevent household transmission. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022-11 2022-09-28 /pmc/articles/PMC9514960/ /pubmed/36180032 http://dx.doi.org/10.1016/j.ijid.2022.09.032 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Muadchimkaew, Marisa Siripongboonsitti, Taweegrit Wongpatcharawarakul, Saowanee Boonsankaew, Chanyapak Tawinprai, Kriangkrai Soonklang, Kamonwan Mahanonda, Nithi Effect of Inactivated SARS-CoV-2 Vaccines and ChAdOx1 nCoV-19 Vaccination to Prevent COVID-19 in Thai Households (VacPrevent trial) |
title | Effect of Inactivated SARS-CoV-2 Vaccines and ChAdOx1 nCoV-19 Vaccination to Prevent COVID-19 in Thai Households (VacPrevent trial) |
title_full | Effect of Inactivated SARS-CoV-2 Vaccines and ChAdOx1 nCoV-19 Vaccination to Prevent COVID-19 in Thai Households (VacPrevent trial) |
title_fullStr | Effect of Inactivated SARS-CoV-2 Vaccines and ChAdOx1 nCoV-19 Vaccination to Prevent COVID-19 in Thai Households (VacPrevent trial) |
title_full_unstemmed | Effect of Inactivated SARS-CoV-2 Vaccines and ChAdOx1 nCoV-19 Vaccination to Prevent COVID-19 in Thai Households (VacPrevent trial) |
title_short | Effect of Inactivated SARS-CoV-2 Vaccines and ChAdOx1 nCoV-19 Vaccination to Prevent COVID-19 in Thai Households (VacPrevent trial) |
title_sort | effect of inactivated sars-cov-2 vaccines and chadox1 ncov-19 vaccination to prevent covid-19 in thai households (vacprevent trial) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514960/ https://www.ncbi.nlm.nih.gov/pubmed/36180032 http://dx.doi.org/10.1016/j.ijid.2022.09.032 |
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