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Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats
In Egypt, both pregabalin and tramadol misuse increased in the last decade. Although many studies have confirmed the neurotoxic effects of tramadol, those of pregabalin are understudied. The aim of the study is to evaluate the neurotoxic effects of pregabalin compared with tramadol. Thirty male albi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515019/ https://www.ncbi.nlm.nih.gov/pubmed/35976555 http://dx.doi.org/10.1007/s12640-022-00557-9 |
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author | Elsukary, Ahmed E. Helaly, Ahmed M. N. Z. El Bakary, Amal A. Moustafa, Maha E. El-Kattan, Mohammad A. |
author_facet | Elsukary, Ahmed E. Helaly, Ahmed M. N. Z. El Bakary, Amal A. Moustafa, Maha E. El-Kattan, Mohammad A. |
author_sort | Elsukary, Ahmed E. |
collection | PubMed |
description | In Egypt, both pregabalin and tramadol misuse increased in the last decade. Although many studies have confirmed the neurotoxic effects of tramadol, those of pregabalin are understudied. The aim of the study is to evaluate the neurotoxic effects of pregabalin compared with tramadol. Thirty male albino rats were included in this experimental study, and they were randomly allocated into three equal groups: group I (normal saline), group II (tramadol misuse), and group III (pregabalin misuse). All rats received the commenced drugs for 1 month. Open field tests were performed on the day of scarification, and after that, cortical samples were taken for immunohistochemical analysis and quantification of dopamine receptors’ gene expression. The drug misuse groups showed a significant decrease in weight gain at the end of the study. Open field testing showed the upper hand of controls regarding all of the tested parameters. Tramadol has a more negative impact on the locomotor parameters compared with pregabalin. Both drugs induced relatively low dopamine-1 receptor (D1Rs) expression to dopamine-2 receptors (D2Rs), mimicking the schizophrenia model. Both tramadol and pregabalin were associated with neurotoxic effects in male albino rats. These effects were less noticed with pregabalin. It is suggested that long-term abuse may end in psychosis. |
format | Online Article Text |
id | pubmed-9515019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-95150192022-09-29 Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats Elsukary, Ahmed E. Helaly, Ahmed M. N. Z. El Bakary, Amal A. Moustafa, Maha E. El-Kattan, Mohammad A. Neurotox Res Research Article In Egypt, both pregabalin and tramadol misuse increased in the last decade. Although many studies have confirmed the neurotoxic effects of tramadol, those of pregabalin are understudied. The aim of the study is to evaluate the neurotoxic effects of pregabalin compared with tramadol. Thirty male albino rats were included in this experimental study, and they were randomly allocated into three equal groups: group I (normal saline), group II (tramadol misuse), and group III (pregabalin misuse). All rats received the commenced drugs for 1 month. Open field tests were performed on the day of scarification, and after that, cortical samples were taken for immunohistochemical analysis and quantification of dopamine receptors’ gene expression. The drug misuse groups showed a significant decrease in weight gain at the end of the study. Open field testing showed the upper hand of controls regarding all of the tested parameters. Tramadol has a more negative impact on the locomotor parameters compared with pregabalin. Both drugs induced relatively low dopamine-1 receptor (D1Rs) expression to dopamine-2 receptors (D2Rs), mimicking the schizophrenia model. Both tramadol and pregabalin were associated with neurotoxic effects in male albino rats. These effects were less noticed with pregabalin. It is suggested that long-term abuse may end in psychosis. Springer US 2022-08-17 2022 /pmc/articles/PMC9515019/ /pubmed/35976555 http://dx.doi.org/10.1007/s12640-022-00557-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Elsukary, Ahmed E. Helaly, Ahmed M. N. Z. El Bakary, Amal A. Moustafa, Maha E. El-Kattan, Mohammad A. Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats |
title | Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats |
title_full | Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats |
title_fullStr | Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats |
title_full_unstemmed | Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats |
title_short | Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats |
title_sort | comparative study of the neurotoxic effects of pregabalin versus tramadol in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515019/ https://www.ncbi.nlm.nih.gov/pubmed/35976555 http://dx.doi.org/10.1007/s12640-022-00557-9 |
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