Identification and verification of CCNB1 as a potential prognostic biomarker by comprehensive analysis

As one of the most common types of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) is highly invasive and lethal. This study aims to develop biomarkers and targets for the diagnosis and treatment of PDAC. Differentially expressed genes (DEGs) were screened via GEO2R, protein network was c...

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Autores principales: Zeng, Yinzhen, Fan, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515086/
https://www.ncbi.nlm.nih.gov/pubmed/36167975
http://dx.doi.org/10.1038/s41598-022-20615-8
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author Zeng, Yinzhen
Fan, Rong
author_facet Zeng, Yinzhen
Fan, Rong
author_sort Zeng, Yinzhen
collection PubMed
description As one of the most common types of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) is highly invasive and lethal. This study aims to develop biomarkers and targets for the diagnosis and treatment of PDAC. Differentially expressed genes (DEGs) were screened via GEO2R, protein network was constructed through STRING and Cytoscape. Functional enrichment analysis was performed, followed by survival analysis and expression validation. A total of 115 DEGs were identified, including 108 upregulated and 7 downregulated genes. After enrichment, survival analysis, one potential gene, Cyclin B1 (CCNB1), was selected for further expression verification at the mRNA and protein level. Taker together, CCNB1 may act as a potential biomarker which provided new idea for elucidation of the pathogenesis of PDAC.
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spelling pubmed-95150862022-09-29 Identification and verification of CCNB1 as a potential prognostic biomarker by comprehensive analysis Zeng, Yinzhen Fan, Rong Sci Rep Article As one of the most common types of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) is highly invasive and lethal. This study aims to develop biomarkers and targets for the diagnosis and treatment of PDAC. Differentially expressed genes (DEGs) were screened via GEO2R, protein network was constructed through STRING and Cytoscape. Functional enrichment analysis was performed, followed by survival analysis and expression validation. A total of 115 DEGs were identified, including 108 upregulated and 7 downregulated genes. After enrichment, survival analysis, one potential gene, Cyclin B1 (CCNB1), was selected for further expression verification at the mRNA and protein level. Taker together, CCNB1 may act as a potential biomarker which provided new idea for elucidation of the pathogenesis of PDAC. Nature Publishing Group UK 2022-09-27 /pmc/articles/PMC9515086/ /pubmed/36167975 http://dx.doi.org/10.1038/s41598-022-20615-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zeng, Yinzhen
Fan, Rong
Identification and verification of CCNB1 as a potential prognostic biomarker by comprehensive analysis
title Identification and verification of CCNB1 as a potential prognostic biomarker by comprehensive analysis
title_full Identification and verification of CCNB1 as a potential prognostic biomarker by comprehensive analysis
title_fullStr Identification and verification of CCNB1 as a potential prognostic biomarker by comprehensive analysis
title_full_unstemmed Identification and verification of CCNB1 as a potential prognostic biomarker by comprehensive analysis
title_short Identification and verification of CCNB1 as a potential prognostic biomarker by comprehensive analysis
title_sort identification and verification of ccnb1 as a potential prognostic biomarker by comprehensive analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515086/
https://www.ncbi.nlm.nih.gov/pubmed/36167975
http://dx.doi.org/10.1038/s41598-022-20615-8
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