A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s

Ageing is co-regulated by genetic and environmental factors. Life on earth lives and evolves in a mild geomagnetic field. Yet, the biological effects of a moderate magnetic field on ageing and the underlying genetic mechanisms remain barely unknown. Here, we report that a moderate static magnetic fi...

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Autores principales: Song, Mengjiao, Dong, Shiming, Zhang, Xiangfei, Dai, Yumin, Zhang, Xin, Shen, Yidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515093/
https://www.ncbi.nlm.nih.gov/pubmed/36167800
http://dx.doi.org/10.1038/s41598-022-20647-0
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author Song, Mengjiao
Dong, Shiming
Zhang, Xiangfei
Dai, Yumin
Zhang, Xin
Shen, Yidong
author_facet Song, Mengjiao
Dong, Shiming
Zhang, Xiangfei
Dai, Yumin
Zhang, Xin
Shen, Yidong
author_sort Song, Mengjiao
collection PubMed
description Ageing is co-regulated by genetic and environmental factors. Life on earth lives and evolves in a mild geomagnetic field. Yet, the biological effects of a moderate magnetic field on ageing and the underlying genetic mechanisms remain barely unknown. Here, we report that a moderate static magnetic field (SMF) extends the lifespan of Caenorhabditis elegans, a well-established model organism in ageing research. Consistently, the SMF-treated worms show improved motility and mitochondrial function when aged. We identified from the transcriptomic changes upon SMF treatment that the upregulation of three cytochrome P450 genes are required for SMF-induced longevity. Our findings thus reveal that proper SMF treatment could promote longevity through the well-conserved cytochrome P450 enzymes.
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spelling pubmed-95150932022-09-29 A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s Song, Mengjiao Dong, Shiming Zhang, Xiangfei Dai, Yumin Zhang, Xin Shen, Yidong Sci Rep Article Ageing is co-regulated by genetic and environmental factors. Life on earth lives and evolves in a mild geomagnetic field. Yet, the biological effects of a moderate magnetic field on ageing and the underlying genetic mechanisms remain barely unknown. Here, we report that a moderate static magnetic field (SMF) extends the lifespan of Caenorhabditis elegans, a well-established model organism in ageing research. Consistently, the SMF-treated worms show improved motility and mitochondrial function when aged. We identified from the transcriptomic changes upon SMF treatment that the upregulation of three cytochrome P450 genes are required for SMF-induced longevity. Our findings thus reveal that proper SMF treatment could promote longevity through the well-conserved cytochrome P450 enzymes. Nature Publishing Group UK 2022-09-27 /pmc/articles/PMC9515093/ /pubmed/36167800 http://dx.doi.org/10.1038/s41598-022-20647-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Song, Mengjiao
Dong, Shiming
Zhang, Xiangfei
Dai, Yumin
Zhang, Xin
Shen, Yidong
A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s
title A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s
title_full A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s
title_fullStr A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s
title_full_unstemmed A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s
title_short A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s
title_sort moderate static magnetic field promotes c. elegans longevity through cytochrome p450s
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515093/
https://www.ncbi.nlm.nih.gov/pubmed/36167800
http://dx.doi.org/10.1038/s41598-022-20647-0
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