Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance

Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction. In the aged brain, senescent cell identities and the mechanisms by which they exert adverse influence are unclear. Here we used high-dimensional molecular profiling, coupled with mechanistic experiments, to study...

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Detalles Bibliográficos
Autores principales: Zhang, Xu, Pearsall, Vesselina M., Carver, Chase M., Atkinson, Elizabeth J., Clarkson, Benjamin D. S., Grund, Ethan M., Baez-Faria, Michelle, Pavelko, Kevin D., Kachergus, Jennifer M., White, Thomas A., Johnson, Renee K., Malo, Courtney S., Gonzalez-Suarez, Alan M., Ayasoufi, Katayoun, Johnson, Kurt O., Tritz, Zachariah P., Fain, Cori E., Khadka, Roman H., Ogrodnik, Mikolaj, Jurk, Diana, Zhu, Yi, Tchkonia, Tamara, Revzin, Alexander, Kirkland, James L., Johnson, Aaron J., Howe, Charles L., Thompson, E. Aubrey, LeBrasseur, Nathan K., Schafer, Marissa J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515187/
https://www.ncbi.nlm.nih.gov/pubmed/36167854
http://dx.doi.org/10.1038/s41467-022-33226-8

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