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Serum leptin and neuropeptide Y in patients with cystic fibrosis—A single center study

Along with the significant elongation in the average life expectancy of patients with cystic fibrosis (CF), there are still significant discrepancies in the height, weight, and body mass index (BMI) of patients compared to controls without CF. The correlation between hormones that regulate appetite...

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Autores principales: Galiniak, Sabina, Podgórski, Rafał, Rachel, Marta, Mazur, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515389/
https://www.ncbi.nlm.nih.gov/pubmed/36186778
http://dx.doi.org/10.3389/fmed.2022.959584
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author Galiniak, Sabina
Podgórski, Rafał
Rachel, Marta
Mazur, Artur
author_facet Galiniak, Sabina
Podgórski, Rafał
Rachel, Marta
Mazur, Artur
author_sort Galiniak, Sabina
collection PubMed
description Along with the significant elongation in the average life expectancy of patients with cystic fibrosis (CF), there are still significant discrepancies in the height, weight, and body mass index (BMI) of patients compared to controls without CF. The correlation between hormones that regulate appetite and body fat mass may be an additional factor in weight loss or poor weight gain in CF patients. Our objective was to estimate serum concentrations of leptin and neuropeptide Y in patients with CF as well as to assess correlations between studied hormones and the clinical parameters of CF. Leptin and neuropeptide Y serum concentrations after an overnight fast were measured using an enzyme-linked immunosorbent assay. All study participants had anthropometric tests and spirometry. In addition, fasting serum lipid profile was also analyzed. Fasting leptin levels in CF were significantly higher in patients with CF patients (13.9 ± 6.9 vs. 6.5 ± 2.6 ng/mL, p < 0.001) compared to controls. There were no differences in leptin concentration between female and male CF participants (15.7 ± 7.8 vs. 12.2 ± 5.6 ng/mL, p = 0.13). Leptin was correlated with age (R = 0.64, p < 0.001), BMI (R = 0.65, p < 0.001), spirometry results (R = −0.49, p < 0.01), and body fat (R = 0.5, p < 0.05). There were no differences in neuropeptide Y concentration between participants with CF and controls as well as neuropeptide Y was not correlated with any studied parameters. The results of our study suggest that weight loss may be associated with a decreased level of leptin, while reduced pulmonary function in CF may be related to an elevated level of leptin.
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spelling pubmed-95153892022-09-29 Serum leptin and neuropeptide Y in patients with cystic fibrosis—A single center study Galiniak, Sabina Podgórski, Rafał Rachel, Marta Mazur, Artur Front Med (Lausanne) Medicine Along with the significant elongation in the average life expectancy of patients with cystic fibrosis (CF), there are still significant discrepancies in the height, weight, and body mass index (BMI) of patients compared to controls without CF. The correlation between hormones that regulate appetite and body fat mass may be an additional factor in weight loss or poor weight gain in CF patients. Our objective was to estimate serum concentrations of leptin and neuropeptide Y in patients with CF as well as to assess correlations between studied hormones and the clinical parameters of CF. Leptin and neuropeptide Y serum concentrations after an overnight fast were measured using an enzyme-linked immunosorbent assay. All study participants had anthropometric tests and spirometry. In addition, fasting serum lipid profile was also analyzed. Fasting leptin levels in CF were significantly higher in patients with CF patients (13.9 ± 6.9 vs. 6.5 ± 2.6 ng/mL, p < 0.001) compared to controls. There were no differences in leptin concentration between female and male CF participants (15.7 ± 7.8 vs. 12.2 ± 5.6 ng/mL, p = 0.13). Leptin was correlated with age (R = 0.64, p < 0.001), BMI (R = 0.65, p < 0.001), spirometry results (R = −0.49, p < 0.01), and body fat (R = 0.5, p < 0.05). There were no differences in neuropeptide Y concentration between participants with CF and controls as well as neuropeptide Y was not correlated with any studied parameters. The results of our study suggest that weight loss may be associated with a decreased level of leptin, while reduced pulmonary function in CF may be related to an elevated level of leptin. Frontiers Media S.A. 2022-09-14 /pmc/articles/PMC9515389/ /pubmed/36186778 http://dx.doi.org/10.3389/fmed.2022.959584 Text en Copyright © 2022 Galiniak, Podgórski, Rachel and Mazur. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Galiniak, Sabina
Podgórski, Rafał
Rachel, Marta
Mazur, Artur
Serum leptin and neuropeptide Y in patients with cystic fibrosis—A single center study
title Serum leptin and neuropeptide Y in patients with cystic fibrosis—A single center study
title_full Serum leptin and neuropeptide Y in patients with cystic fibrosis—A single center study
title_fullStr Serum leptin and neuropeptide Y in patients with cystic fibrosis—A single center study
title_full_unstemmed Serum leptin and neuropeptide Y in patients with cystic fibrosis—A single center study
title_short Serum leptin and neuropeptide Y in patients with cystic fibrosis—A single center study
title_sort serum leptin and neuropeptide y in patients with cystic fibrosis—a single center study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515389/
https://www.ncbi.nlm.nih.gov/pubmed/36186778
http://dx.doi.org/10.3389/fmed.2022.959584
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