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Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children

Background: Severe malarial anemia (SMA; Hb < 5.0 g/dl) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions such as western Kenya. Methods: We investigated the relationship between two novel complement component 5 (C5) missense mutatio...

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Detalles Bibliográficos
Autores principales:	Raballah, Evans, Wilding, Kristen, Anyona, Samuel B., Munde, Elly O., Hurwitz, Ivy, Onyango, Clinton O., Ayieko, Cyrus, Lambert, Christophe G., Schneider, Kristan A., Seidenberg, Philip D., Ouma, Collins, McMahon, Benjamin H., Cheng, Qiuying, Perkins, Douglas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515573/ https://www.ncbi.nlm.nih.gov/pubmed/36186473 http://dx.doi.org/10.3389/fgene.2022.977810

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