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The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study

Observational studies have indicated the associations between obesity with bone mineral density (BMD) and fracture but yield inconsistent results. The impact of childhood obesity on bone health in adulthood is even less clear. The present study adopted the Mendelian randomization methods to determin...

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Autores principales: Liang, Yuehui, Deng, Ming-Gang, Jian, Qinghong, Zhang, Minjie, Chen, Shuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515586/
https://www.ncbi.nlm.nih.gov/pubmed/36185695
http://dx.doi.org/10.3389/fnut.2022.945125
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author Liang, Yuehui
Deng, Ming-Gang
Jian, Qinghong
Zhang, Minjie
Chen, Shuai
author_facet Liang, Yuehui
Deng, Ming-Gang
Jian, Qinghong
Zhang, Minjie
Chen, Shuai
author_sort Liang, Yuehui
collection PubMed
description Observational studies have indicated the associations between obesity with bone mineral density (BMD) and fracture but yield inconsistent results. The impact of childhood obesity on bone health in adulthood is even less clear. The present study adopted the Mendelian randomization methods to determine whether the genetically predicted childhood obesity was causally associated with BMD and the risk of fracture. Genetic variants were extracted from genome-wide association studies (GWAS) to identify childhood obesity loci [IEU open GWAS project: childhood obesity (ID: ieu-a-1096)] and single nucleotide polymorphisms (SNPs) as instrumental variables to investigate causality. We used two-sample univariable Mendelian randomization (MR) to estimate causal relationships between childhood obesity on BMD and fracture subtypes based on SNPs from European samples. To avoid bias, Cochran's Q test and leave-one-out variant analysis were performed. The MR analysis shows strong evidence that childhood obesity is causally associated with eBMD (OR 1.068, 95% CI 1.043–1.095, P < 0.001) and a weak decreased risk of leg fracture (OR 0.9990, 95% CI 0.9981–0.9999, P =0.033) based on the inverse variance weighting (IVW) method. After adjusting for diabetes and adult obesity, the results of eBMD remained the same. The MR analysis revealed sufficient evidence to indicate childhood obesity was causally associated with increased BMD and decreased risk of leg fracture in adults. Childhood obesity could be taken into consideration when assessing eBMD.
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spelling pubmed-95155862022-09-29 The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study Liang, Yuehui Deng, Ming-Gang Jian, Qinghong Zhang, Minjie Chen, Shuai Front Nutr Nutrition Observational studies have indicated the associations between obesity with bone mineral density (BMD) and fracture but yield inconsistent results. The impact of childhood obesity on bone health in adulthood is even less clear. The present study adopted the Mendelian randomization methods to determine whether the genetically predicted childhood obesity was causally associated with BMD and the risk of fracture. Genetic variants were extracted from genome-wide association studies (GWAS) to identify childhood obesity loci [IEU open GWAS project: childhood obesity (ID: ieu-a-1096)] and single nucleotide polymorphisms (SNPs) as instrumental variables to investigate causality. We used two-sample univariable Mendelian randomization (MR) to estimate causal relationships between childhood obesity on BMD and fracture subtypes based on SNPs from European samples. To avoid bias, Cochran's Q test and leave-one-out variant analysis were performed. The MR analysis shows strong evidence that childhood obesity is causally associated with eBMD (OR 1.068, 95% CI 1.043–1.095, P < 0.001) and a weak decreased risk of leg fracture (OR 0.9990, 95% CI 0.9981–0.9999, P =0.033) based on the inverse variance weighting (IVW) method. After adjusting for diabetes and adult obesity, the results of eBMD remained the same. The MR analysis revealed sufficient evidence to indicate childhood obesity was causally associated with increased BMD and decreased risk of leg fracture in adults. Childhood obesity could be taken into consideration when assessing eBMD. Frontiers Media S.A. 2022-09-14 /pmc/articles/PMC9515586/ /pubmed/36185695 http://dx.doi.org/10.3389/fnut.2022.945125 Text en Copyright © 2022 Liang, Deng, Jian, Zhang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Liang, Yuehui
Deng, Ming-Gang
Jian, Qinghong
Zhang, Minjie
Chen, Shuai
The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study
title The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study
title_full The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study
title_fullStr The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study
title_full_unstemmed The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study
title_short The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study
title_sort causal impact of childhood obesity on bone mineral density and fracture in adulthood: a two-sample mendelian randomization study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515586/
https://www.ncbi.nlm.nih.gov/pubmed/36185695
http://dx.doi.org/10.3389/fnut.2022.945125
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