Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions

The chemoenzymatic synthesis of a series of dual N- and C-terminal–functionalized cholera toxin B subunit (CTB) glycoconjugates is described. Mucin 1 peptides bearing different levels of Tn antigen glycosylation [MUC1(Tn)] were prepared via solid-phase peptide synthesis. Using sortase-mediated ligat...

Descripción completa

Detalles Bibliográficos
Autores principales: Dolan, Jonathan P., Machin, Darren C., Dedola, Simone, Field, Robert A., Webb, Michael E., Turnbull, W. Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515619/
https://www.ncbi.nlm.nih.gov/pubmed/36186584
http://dx.doi.org/10.3389/fchem.2022.958272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515619/
https://www.ncbi.nlm.nih.gov/pubmed/36186584
http://dx.doi.org/10.3389/fchem.2022.958272

Ejemplares similares