Cargando…

Testing the protein-leverage hypothesis using population surveillance data

It is hypothesized that humans exhibit ‘protein leverage’ (PL), whereby regulation of absolute protein intake results in the over-consumption of non-protein food on low percentage protein diets. Testing for PL using dietary surveillance data involves seeking evidence for a negative association betwe...

Descripción completa

Detalles Bibliográficos
Autores principales: Senior, Alistair M., Raubenheimer, David, Simpson, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515627/
https://www.ncbi.nlm.nih.gov/pubmed/36177194
http://dx.doi.org/10.1098/rsos.220756
_version_ 1784798526660673536
author Senior, Alistair M.
Raubenheimer, David
Simpson, Stephen J.
author_facet Senior, Alistair M.
Raubenheimer, David
Simpson, Stephen J.
author_sort Senior, Alistair M.
collection PubMed
description It is hypothesized that humans exhibit ‘protein leverage’ (PL), whereby regulation of absolute protein intake results in the over-consumption of non-protein food on low percentage protein diets. Testing for PL using dietary surveillance data involves seeking evidence for a negative association between total energy intake and percentage energy from protein. However, it is unclear whether such an association might emerge without PL due to the structure of intake data (protein and non-protein intakes have different means and variances and covary). We derive a set of models that describe the association between the expected estimate of PL and the distributions of protein and non-protein intake. Models were validated via simulation. Patterns consistent with PL will not emerge simply because protein intake has a lower mean and/or variance than non-protein. Rather, evidence of PL is observed where protein has a lower index of dispersion (variance/mean) than non-protein intake. Reciprocally, the stronger PL is the lower the index of dispersion for protein intake becomes. Disentangling causality is ultimately beyond the power of observational data alone. However, we show that one can correct for confounders (e.g. age) in generating signals of PL, and describe independent measures that can anchor inferences around the role of PL.
format Online
Article
Text
id pubmed-9515627
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-95156272022-09-28 Testing the protein-leverage hypothesis using population surveillance data Senior, Alistair M. Raubenheimer, David Simpson, Stephen J. R Soc Open Sci Organismal and Evolutionary Biology It is hypothesized that humans exhibit ‘protein leverage’ (PL), whereby regulation of absolute protein intake results in the over-consumption of non-protein food on low percentage protein diets. Testing for PL using dietary surveillance data involves seeking evidence for a negative association between total energy intake and percentage energy from protein. However, it is unclear whether such an association might emerge without PL due to the structure of intake data (protein and non-protein intakes have different means and variances and covary). We derive a set of models that describe the association between the expected estimate of PL and the distributions of protein and non-protein intake. Models were validated via simulation. Patterns consistent with PL will not emerge simply because protein intake has a lower mean and/or variance than non-protein. Rather, evidence of PL is observed where protein has a lower index of dispersion (variance/mean) than non-protein intake. Reciprocally, the stronger PL is the lower the index of dispersion for protein intake becomes. Disentangling causality is ultimately beyond the power of observational data alone. However, we show that one can correct for confounders (e.g. age) in generating signals of PL, and describe independent measures that can anchor inferences around the role of PL. The Royal Society 2022-09-28 /pmc/articles/PMC9515627/ /pubmed/36177194 http://dx.doi.org/10.1098/rsos.220756 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Organismal and Evolutionary Biology
Senior, Alistair M.
Raubenheimer, David
Simpson, Stephen J.
Testing the protein-leverage hypothesis using population surveillance data
title Testing the protein-leverage hypothesis using population surveillance data
title_full Testing the protein-leverage hypothesis using population surveillance data
title_fullStr Testing the protein-leverage hypothesis using population surveillance data
title_full_unstemmed Testing the protein-leverage hypothesis using population surveillance data
title_short Testing the protein-leverage hypothesis using population surveillance data
title_sort testing the protein-leverage hypothesis using population surveillance data
topic Organismal and Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515627/
https://www.ncbi.nlm.nih.gov/pubmed/36177194
http://dx.doi.org/10.1098/rsos.220756
work_keys_str_mv AT senioralistairm testingtheproteinleveragehypothesisusingpopulationsurveillancedata
AT raubenheimerdavid testingtheproteinleveragehypothesisusingpopulationsurveillancedata
AT simpsonstephenj testingtheproteinleveragehypothesisusingpopulationsurveillancedata