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Cystargolide-based amide and ester Pz analogues as proteasome inhibitors and anti-cancer agents

A series of cystargolide-based β-lactone analogues containing nitrogen atoms at the Pz portion of the scaffold were prepared and evaluated as proteasome inhibitors, and for their cytotoxicity profile toward several cancer cell lines. Inclusion of one, two or even three nitrogen atoms at the Pz porti...

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Detalles Bibliográficos
Autores principales:	Viera, Carlos R., Stevens, Bradley T., Viera, Talysa, Zielinski, Cameron, Uranga, Lee A., Rogelj, Snezna, Patidar, Praveen L., Tello-Aburto, Rodolfo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515629/ https://www.ncbi.nlm.nih.gov/pubmed/36177203 http://dx.doi.org/10.1098/rsos.220358

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