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The Role of Inflammasome NLPR3 in the Development and Therapy of Periodontitis
Periodontitis is a chronic inflammatory disease that affects tooth-supporting tissues and even leads to tooth loss. NLRP3 inflammasomes play a critical role in periodontitis pathogenesis. Aberrant activation or overexpression of NLRP3 inflammasomes in cellular players, including osteoclasts, osteobl...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515687/ https://www.ncbi.nlm.nih.gov/pubmed/36185327 http://dx.doi.org/10.7150/ijms.74575 |
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author | Zhao, Ying Quan, Yue Lei, Ting Fan, Liumeizi Ge, Xin Hu, Sheng |
author_facet | Zhao, Ying Quan, Yue Lei, Ting Fan, Liumeizi Ge, Xin Hu, Sheng |
author_sort | Zhao, Ying |
collection | PubMed |
description | Periodontitis is a chronic inflammatory disease that affects tooth-supporting tissues and even leads to tooth loss. NLRP3 inflammasomes play a critical role in periodontitis pathogenesis. Aberrant activation or overexpression of NLRP3 inflammasomes in cellular players, including osteoclasts, osteoblasts, periodontal ligament fibroblasts, and leukocytes often contributes to cellular dysfunction and environment abnormality, thus resulting in the disorganization of ligament and alveolar bone. In this review, we mainly focus on the negative regulation of NLRP3 inflammasome in periodontitis and highlight the importance of NLRP3 inflammasome as a candidate therapeutic target in periodontitis treatment. Then we elucidate the development status of NLRP3 inflammasome inhibitors and show their application potential for treating periodontitis. In summary, this review reveals the recent progress and perspectives of NLRP3 inflammasome and the therapeutic potential of NLRP3 inflammasome inhibitors in periodontitis. |
format | Online Article Text |
id | pubmed-9515687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-95156872022-09-29 The Role of Inflammasome NLPR3 in the Development and Therapy of Periodontitis Zhao, Ying Quan, Yue Lei, Ting Fan, Liumeizi Ge, Xin Hu, Sheng Int J Med Sci Review Periodontitis is a chronic inflammatory disease that affects tooth-supporting tissues and even leads to tooth loss. NLRP3 inflammasomes play a critical role in periodontitis pathogenesis. Aberrant activation or overexpression of NLRP3 inflammasomes in cellular players, including osteoclasts, osteoblasts, periodontal ligament fibroblasts, and leukocytes often contributes to cellular dysfunction and environment abnormality, thus resulting in the disorganization of ligament and alveolar bone. In this review, we mainly focus on the negative regulation of NLRP3 inflammasome in periodontitis and highlight the importance of NLRP3 inflammasome as a candidate therapeutic target in periodontitis treatment. Then we elucidate the development status of NLRP3 inflammasome inhibitors and show their application potential for treating periodontitis. In summary, this review reveals the recent progress and perspectives of NLRP3 inflammasome and the therapeutic potential of NLRP3 inflammasome inhibitors in periodontitis. Ivyspring International Publisher 2022-09-21 /pmc/articles/PMC9515687/ /pubmed/36185327 http://dx.doi.org/10.7150/ijms.74575 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Zhao, Ying Quan, Yue Lei, Ting Fan, Liumeizi Ge, Xin Hu, Sheng The Role of Inflammasome NLPR3 in the Development and Therapy of Periodontitis |
title | The Role of Inflammasome NLPR3 in the Development and Therapy of Periodontitis |
title_full | The Role of Inflammasome NLPR3 in the Development and Therapy of Periodontitis |
title_fullStr | The Role of Inflammasome NLPR3 in the Development and Therapy of Periodontitis |
title_full_unstemmed | The Role of Inflammasome NLPR3 in the Development and Therapy of Periodontitis |
title_short | The Role of Inflammasome NLPR3 in the Development and Therapy of Periodontitis |
title_sort | role of inflammasome nlpr3 in the development and therapy of periodontitis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515687/ https://www.ncbi.nlm.nih.gov/pubmed/36185327 http://dx.doi.org/10.7150/ijms.74575 |
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