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Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia

Preeclampsia, a clinical syndrome mainly characterized by hypertension and proteinuria, with a worldwide incidence of 3–8% and high maternal mortality, is a risk factor highly associated with maternal and offspring cardiovascular disease. However, the etiology and pathogenesis of preeclampsia are co...

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Autores principales: Yin, Aiqi, Guan, Xiaonian, Zhang, Jian V., Niu, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515905/
https://www.ncbi.nlm.nih.gov/pubmed/36187484
http://dx.doi.org/10.3389/fcell.2022.959239
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author Yin, Aiqi
Guan, Xiaonian
Zhang, Jian V.
Niu, Jianmin
author_facet Yin, Aiqi
Guan, Xiaonian
Zhang, Jian V.
Niu, Jianmin
author_sort Yin, Aiqi
collection PubMed
description Preeclampsia, a clinical syndrome mainly characterized by hypertension and proteinuria, with a worldwide incidence of 3–8% and high maternal mortality, is a risk factor highly associated with maternal and offspring cardiovascular disease. However, the etiology and pathogenesis of preeclampsia are complicated and have not been fully elucidated. Obesity, immunological diseases and endocrine metabolic diseases are high-risk factors for the development of preeclampsia. Effective methods to treat preeclampsia are lacking, and termination of pregnancy remains the only curative treatment for preeclampsia. The pathogenesis of preeclampsia include poor placentation, uteroplacental malperfusion, oxidative stress, endoplasmic reticulum stress, dysregulated immune tolerance, vascular inflammation and endothelial cell dysfunction. The notion that placenta is the core factor in the pathogenesis of preeclampsia is still prevailing. G protein-coupled receptors, the largest family of membrane proteins in eukaryotes and the largest drug target family to date, exhibit diversity in structure and function. Among them, the secretin/adhesion (Class B) G protein-coupled receptors are essential drug targets for human diseases, such as endocrine diseases and cardiometabolic diseases. Given the great value of the secretin/adhesion (Class B) G protein-coupled receptors in the regulation of cardiovascular system function and the drug target exploration, we summarize the role of these receptors in placental development and preeclampsia, and outlined the relevant pathological mechanisms, thereby providing potential drug targets for preeclampsia treatment.
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spelling pubmed-95159052022-09-29 Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia Yin, Aiqi Guan, Xiaonian Zhang, Jian V. Niu, Jianmin Front Cell Dev Biol Cell and Developmental Biology Preeclampsia, a clinical syndrome mainly characterized by hypertension and proteinuria, with a worldwide incidence of 3–8% and high maternal mortality, is a risk factor highly associated with maternal and offspring cardiovascular disease. However, the etiology and pathogenesis of preeclampsia are complicated and have not been fully elucidated. Obesity, immunological diseases and endocrine metabolic diseases are high-risk factors for the development of preeclampsia. Effective methods to treat preeclampsia are lacking, and termination of pregnancy remains the only curative treatment for preeclampsia. The pathogenesis of preeclampsia include poor placentation, uteroplacental malperfusion, oxidative stress, endoplasmic reticulum stress, dysregulated immune tolerance, vascular inflammation and endothelial cell dysfunction. The notion that placenta is the core factor in the pathogenesis of preeclampsia is still prevailing. G protein-coupled receptors, the largest family of membrane proteins in eukaryotes and the largest drug target family to date, exhibit diversity in structure and function. Among them, the secretin/adhesion (Class B) G protein-coupled receptors are essential drug targets for human diseases, such as endocrine diseases and cardiometabolic diseases. Given the great value of the secretin/adhesion (Class B) G protein-coupled receptors in the regulation of cardiovascular system function and the drug target exploration, we summarize the role of these receptors in placental development and preeclampsia, and outlined the relevant pathological mechanisms, thereby providing potential drug targets for preeclampsia treatment. Frontiers Media S.A. 2022-09-14 /pmc/articles/PMC9515905/ /pubmed/36187484 http://dx.doi.org/10.3389/fcell.2022.959239 Text en Copyright © 2022 Yin, Guan, Zhang and Niu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Yin, Aiqi
Guan, Xiaonian
Zhang, Jian V.
Niu, Jianmin
Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia
title Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia
title_full Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia
title_fullStr Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia
title_full_unstemmed Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia
title_short Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia
title_sort focusing on the role of secretin/adhesion (class b) g protein-coupled receptors in placental development and preeclampsia
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515905/
https://www.ncbi.nlm.nih.gov/pubmed/36187484
http://dx.doi.org/10.3389/fcell.2022.959239
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