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Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia
Preeclampsia, a clinical syndrome mainly characterized by hypertension and proteinuria, with a worldwide incidence of 3–8% and high maternal mortality, is a risk factor highly associated with maternal and offspring cardiovascular disease. However, the etiology and pathogenesis of preeclampsia are co...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515905/ https://www.ncbi.nlm.nih.gov/pubmed/36187484 http://dx.doi.org/10.3389/fcell.2022.959239 |
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author | Yin, Aiqi Guan, Xiaonian Zhang, Jian V. Niu, Jianmin |
author_facet | Yin, Aiqi Guan, Xiaonian Zhang, Jian V. Niu, Jianmin |
author_sort | Yin, Aiqi |
collection | PubMed |
description | Preeclampsia, a clinical syndrome mainly characterized by hypertension and proteinuria, with a worldwide incidence of 3–8% and high maternal mortality, is a risk factor highly associated with maternal and offspring cardiovascular disease. However, the etiology and pathogenesis of preeclampsia are complicated and have not been fully elucidated. Obesity, immunological diseases and endocrine metabolic diseases are high-risk factors for the development of preeclampsia. Effective methods to treat preeclampsia are lacking, and termination of pregnancy remains the only curative treatment for preeclampsia. The pathogenesis of preeclampsia include poor placentation, uteroplacental malperfusion, oxidative stress, endoplasmic reticulum stress, dysregulated immune tolerance, vascular inflammation and endothelial cell dysfunction. The notion that placenta is the core factor in the pathogenesis of preeclampsia is still prevailing. G protein-coupled receptors, the largest family of membrane proteins in eukaryotes and the largest drug target family to date, exhibit diversity in structure and function. Among them, the secretin/adhesion (Class B) G protein-coupled receptors are essential drug targets for human diseases, such as endocrine diseases and cardiometabolic diseases. Given the great value of the secretin/adhesion (Class B) G protein-coupled receptors in the regulation of cardiovascular system function and the drug target exploration, we summarize the role of these receptors in placental development and preeclampsia, and outlined the relevant pathological mechanisms, thereby providing potential drug targets for preeclampsia treatment. |
format | Online Article Text |
id | pubmed-9515905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95159052022-09-29 Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia Yin, Aiqi Guan, Xiaonian Zhang, Jian V. Niu, Jianmin Front Cell Dev Biol Cell and Developmental Biology Preeclampsia, a clinical syndrome mainly characterized by hypertension and proteinuria, with a worldwide incidence of 3–8% and high maternal mortality, is a risk factor highly associated with maternal and offspring cardiovascular disease. However, the etiology and pathogenesis of preeclampsia are complicated and have not been fully elucidated. Obesity, immunological diseases and endocrine metabolic diseases are high-risk factors for the development of preeclampsia. Effective methods to treat preeclampsia are lacking, and termination of pregnancy remains the only curative treatment for preeclampsia. The pathogenesis of preeclampsia include poor placentation, uteroplacental malperfusion, oxidative stress, endoplasmic reticulum stress, dysregulated immune tolerance, vascular inflammation and endothelial cell dysfunction. The notion that placenta is the core factor in the pathogenesis of preeclampsia is still prevailing. G protein-coupled receptors, the largest family of membrane proteins in eukaryotes and the largest drug target family to date, exhibit diversity in structure and function. Among them, the secretin/adhesion (Class B) G protein-coupled receptors are essential drug targets for human diseases, such as endocrine diseases and cardiometabolic diseases. Given the great value of the secretin/adhesion (Class B) G protein-coupled receptors in the regulation of cardiovascular system function and the drug target exploration, we summarize the role of these receptors in placental development and preeclampsia, and outlined the relevant pathological mechanisms, thereby providing potential drug targets for preeclampsia treatment. Frontiers Media S.A. 2022-09-14 /pmc/articles/PMC9515905/ /pubmed/36187484 http://dx.doi.org/10.3389/fcell.2022.959239 Text en Copyright © 2022 Yin, Guan, Zhang and Niu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Yin, Aiqi Guan, Xiaonian Zhang, Jian V. Niu, Jianmin Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia |
title | Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia |
title_full | Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia |
title_fullStr | Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia |
title_full_unstemmed | Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia |
title_short | Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia |
title_sort | focusing on the role of secretin/adhesion (class b) g protein-coupled receptors in placental development and preeclampsia |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515905/ https://www.ncbi.nlm.nih.gov/pubmed/36187484 http://dx.doi.org/10.3389/fcell.2022.959239 |
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