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Evaluation of postoperative feeding strategies in children with intestinal atresia: A single-center retrospective study

OBJECTIVES: Postoperative enteral nutrition has a significant influence on the prognosis of patients with congenital intestinal atresia. Currently, there is no precise guidance on enteral nutrition management. This study aimed to compare the outcomes of different feeding strategies based on the init...

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Autores principales: Wang, Jiepin, Xu, Haozhong, Wang, Junxiang, Xiao, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515948/
https://www.ncbi.nlm.nih.gov/pubmed/36186653
http://dx.doi.org/10.3389/fped.2022.953852
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author Wang, Jiepin
Xu, Haozhong
Wang, Junxiang
Xiao, Dong
author_facet Wang, Jiepin
Xu, Haozhong
Wang, Junxiang
Xiao, Dong
author_sort Wang, Jiepin
collection PubMed
description OBJECTIVES: Postoperative enteral nutrition has a significant influence on the prognosis of patients with congenital intestinal atresia. Currently, there is no precise guidance on enteral nutrition management. This study aimed to compare the outcomes of different feeding strategies based on the initial volume and daily advancement in postoperative patients with congenital intestinal atresia. METHODS: This study was a retrospective study collected from October 2019 to July 2021 in Shenzhen Children's Hospital. According to the initial volume and daily advancement, the patients were divided into high-dose group and low-dose group. General basic information such as age, sex, and lesion type was gathered. The postoperative outcome included the levels of hemoglobin (HGB), albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), direct bilirubin (DB), length of stay, length of total PN, time to reach 100% enteral nutrition (EN) (120 kcal·kg-1·d-1), infection incidence and intestinal failure associated liver disease (IFALD) incidence (DB>2 mg·dL-1). RESULTS: In total, 32 patients with congenital intestinal atresia were identified. There was no significant difference between the high-dose group and the low-dose group in the baseline characteristic. The length of time to reach 100% (p = 0.001) enteral nutrition and postoperative hospital stay (p = 0.092) were shorter in the high-dose group. In the high-dose group, patients at discharge were with not only lower levels of DB (p = 0.009), AST (p = 0.109) and ALT (p = 0.045) but also higher level of ALB (p = 0.459) and hemoglobin (p = 0.354). The incidence of IFALD was significantly lower in the high-dose group (p = 0.032). There was no significant difference in the overall incidence of postoperative complications. CONCLUSIONS: Within the limitations, the findings of this study suggest that High-dose feeding (initial volume>15 ml·kg-1·d-1, daily advancement>10 ml·kg-1·d-1) is beneficial for the prognosis of patients diagnosed with congenital intestinal atresia treated by intestinal.
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spelling pubmed-95159482022-09-29 Evaluation of postoperative feeding strategies in children with intestinal atresia: A single-center retrospective study Wang, Jiepin Xu, Haozhong Wang, Junxiang Xiao, Dong Front Pediatr Pediatrics OBJECTIVES: Postoperative enteral nutrition has a significant influence on the prognosis of patients with congenital intestinal atresia. Currently, there is no precise guidance on enteral nutrition management. This study aimed to compare the outcomes of different feeding strategies based on the initial volume and daily advancement in postoperative patients with congenital intestinal atresia. METHODS: This study was a retrospective study collected from October 2019 to July 2021 in Shenzhen Children's Hospital. According to the initial volume and daily advancement, the patients were divided into high-dose group and low-dose group. General basic information such as age, sex, and lesion type was gathered. The postoperative outcome included the levels of hemoglobin (HGB), albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), direct bilirubin (DB), length of stay, length of total PN, time to reach 100% enteral nutrition (EN) (120 kcal·kg-1·d-1), infection incidence and intestinal failure associated liver disease (IFALD) incidence (DB>2 mg·dL-1). RESULTS: In total, 32 patients with congenital intestinal atresia were identified. There was no significant difference between the high-dose group and the low-dose group in the baseline characteristic. The length of time to reach 100% (p = 0.001) enteral nutrition and postoperative hospital stay (p = 0.092) were shorter in the high-dose group. In the high-dose group, patients at discharge were with not only lower levels of DB (p = 0.009), AST (p = 0.109) and ALT (p = 0.045) but also higher level of ALB (p = 0.459) and hemoglobin (p = 0.354). The incidence of IFALD was significantly lower in the high-dose group (p = 0.032). There was no significant difference in the overall incidence of postoperative complications. CONCLUSIONS: Within the limitations, the findings of this study suggest that High-dose feeding (initial volume>15 ml·kg-1·d-1, daily advancement>10 ml·kg-1·d-1) is beneficial for the prognosis of patients diagnosed with congenital intestinal atresia treated by intestinal. Frontiers Media S.A. 2022-09-14 /pmc/articles/PMC9515948/ /pubmed/36186653 http://dx.doi.org/10.3389/fped.2022.953852 Text en Copyright © 2022 Wang, Xu, Wang and Xiao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Wang, Jiepin
Xu, Haozhong
Wang, Junxiang
Xiao, Dong
Evaluation of postoperative feeding strategies in children with intestinal atresia: A single-center retrospective study
title Evaluation of postoperative feeding strategies in children with intestinal atresia: A single-center retrospective study
title_full Evaluation of postoperative feeding strategies in children with intestinal atresia: A single-center retrospective study
title_fullStr Evaluation of postoperative feeding strategies in children with intestinal atresia: A single-center retrospective study
title_full_unstemmed Evaluation of postoperative feeding strategies in children with intestinal atresia: A single-center retrospective study
title_short Evaluation of postoperative feeding strategies in children with intestinal atresia: A single-center retrospective study
title_sort evaluation of postoperative feeding strategies in children with intestinal atresia: a single-center retrospective study
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515948/
https://www.ncbi.nlm.nih.gov/pubmed/36186653
http://dx.doi.org/10.3389/fped.2022.953852
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