Cargando…

S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1

Recurrent pregnancy loss (RPL) is a severe complication of pregnancy that is caused by genetic abnormalities, immune dysfunction, aberrant cell biology, and tissue structure destruction. Among which, placental dysfunction is crucial in the pathogenetic progression of RPL. Although some regulatory fa...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Hanjing, Pan, Yibin, Yang, Weijie, Zhao, Chenqiong, Sun, Xiaohe, Hong, Binbin, Jin, Xiaoying, Zhang, Tai, Zhang, Yinli, Liu, Na, Zhang, Songying, Zhu, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515983/
https://www.ncbi.nlm.nih.gov/pubmed/36187124
http://dx.doi.org/10.3389/fendo.2022.860261
_version_ 1784798613017198592
author Zhou, Hanjing
Pan, Yibin
Yang, Weijie
Zhao, Chenqiong
Sun, Xiaohe
Hong, Binbin
Jin, Xiaoying
Zhang, Tai
Zhang, Yinli
Liu, Na
Zhang, Songying
Zhu, Haiyan
author_facet Zhou, Hanjing
Pan, Yibin
Yang, Weijie
Zhao, Chenqiong
Sun, Xiaohe
Hong, Binbin
Jin, Xiaoying
Zhang, Tai
Zhang, Yinli
Liu, Na
Zhang, Songying
Zhu, Haiyan
author_sort Zhou, Hanjing
collection PubMed
description Recurrent pregnancy loss (RPL) is a severe complication of pregnancy that is caused by genetic abnormalities, immune dysfunction, aberrant cell biology, and tissue structure destruction. Among which, placental dysfunction is crucial in the pathogenetic progression of RPL. Although some regulatory factors associated with RPL have been reported, the placental changes correlated with RPL still need to be elucidated. Here, we found that a portion of RPL patients presented with low serum and placental S100P expression. Using a human trophoblast stem cell model, we demonstrated that S100P was exclusively expressed in syncytiotrophoblast (ST)-like syncytia (ST(2D)-TS(CT)) and that loss of S100P expression in ST(2D)-TS(CT) cells impaired β-hCG secretion, leading to syncytialization failure during early placental development. Moreover, we found that S100P is involved in regulating trophoblast syncytialization by downregulating the protein level of Yes-associated protein 1 (YAP1), which plays a pivotal role in maintaining trophoblast stemness. Together, our findings suggest that S100P plays an essential role in regulating trophoblast syncytialization during early placental development in humans via YAP1. Additionally, lower serum S100P levels may predict poor pregnancy outcomes and represent a potentially useful marker for evaluating placental biological function during early pregnancy.
format Online
Article
Text
id pubmed-9515983
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95159832022-09-29 S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1 Zhou, Hanjing Pan, Yibin Yang, Weijie Zhao, Chenqiong Sun, Xiaohe Hong, Binbin Jin, Xiaoying Zhang, Tai Zhang, Yinli Liu, Na Zhang, Songying Zhu, Haiyan Front Endocrinol (Lausanne) Endocrinology Recurrent pregnancy loss (RPL) is a severe complication of pregnancy that is caused by genetic abnormalities, immune dysfunction, aberrant cell biology, and tissue structure destruction. Among which, placental dysfunction is crucial in the pathogenetic progression of RPL. Although some regulatory factors associated with RPL have been reported, the placental changes correlated with RPL still need to be elucidated. Here, we found that a portion of RPL patients presented with low serum and placental S100P expression. Using a human trophoblast stem cell model, we demonstrated that S100P was exclusively expressed in syncytiotrophoblast (ST)-like syncytia (ST(2D)-TS(CT)) and that loss of S100P expression in ST(2D)-TS(CT) cells impaired β-hCG secretion, leading to syncytialization failure during early placental development. Moreover, we found that S100P is involved in regulating trophoblast syncytialization by downregulating the protein level of Yes-associated protein 1 (YAP1), which plays a pivotal role in maintaining trophoblast stemness. Together, our findings suggest that S100P plays an essential role in regulating trophoblast syncytialization during early placental development in humans via YAP1. Additionally, lower serum S100P levels may predict poor pregnancy outcomes and represent a potentially useful marker for evaluating placental biological function during early pregnancy. Frontiers Media S.A. 2022-09-14 /pmc/articles/PMC9515983/ /pubmed/36187124 http://dx.doi.org/10.3389/fendo.2022.860261 Text en Copyright © 2022 Zhou, Pan, Yang, Zhao, Sun, Hong, Jin, Zhang, Zhang, Liu, Zhang and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhou, Hanjing
Pan, Yibin
Yang, Weijie
Zhao, Chenqiong
Sun, Xiaohe
Hong, Binbin
Jin, Xiaoying
Zhang, Tai
Zhang, Yinli
Liu, Na
Zhang, Songying
Zhu, Haiyan
S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1
title S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1
title_full S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1
title_fullStr S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1
title_full_unstemmed S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1
title_short S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1
title_sort s100p promotes trophoblast syncytialization during early placenta development by regulating yap1
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515983/
https://www.ncbi.nlm.nih.gov/pubmed/36187124
http://dx.doi.org/10.3389/fendo.2022.860261
work_keys_str_mv AT zhouhanjing s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1
AT panyibin s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1
AT yangweijie s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1
AT zhaochenqiong s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1
AT sunxiaohe s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1
AT hongbinbin s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1
AT jinxiaoying s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1
AT zhangtai s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1
AT zhangyinli s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1
AT liuna s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1
AT zhangsongying s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1
AT zhuhaiyan s100ppromotestrophoblastsyncytializationduringearlyplacentadevelopmentbyregulatingyap1