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Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes

CONTEXT: Endothelial dysfunction may occur early in the development of cardiovascular and metabolic diseases; however, it remains often underestimated and studies rarely discriminate between diabetes types. We have examined endothelial function and its determinants during the early course of type 1...

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Autores principales: Zaharia, Oana Patricia, Schön, Martin, Löffler, Luca, Strassburger, Klaus, Möser, Clara, Yurchenko, Iryna, Bódis, Kálmán, Antoniou, Sofia, Karusheva, Yanislava, Szendroedi, Julia, Burkart, Volker, Roden, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516081/
https://www.ncbi.nlm.nih.gov/pubmed/35965389
http://dx.doi.org/10.1210/clinem/dgac480
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author Zaharia, Oana Patricia
Schön, Martin
Löffler, Luca
Strassburger, Klaus
Möser, Clara
Yurchenko, Iryna
Bódis, Kálmán
Antoniou, Sofia
Karusheva, Yanislava
Szendroedi, Julia
Burkart, Volker
Roden, Michael
author_facet Zaharia, Oana Patricia
Schön, Martin
Löffler, Luca
Strassburger, Klaus
Möser, Clara
Yurchenko, Iryna
Bódis, Kálmán
Antoniou, Sofia
Karusheva, Yanislava
Szendroedi, Julia
Burkart, Volker
Roden, Michael
author_sort Zaharia, Oana Patricia
collection PubMed
description CONTEXT: Endothelial dysfunction may occur early in the development of cardiovascular and metabolic diseases; however, it remains often underestimated and studies rarely discriminate between diabetes types. We have examined endothelial function and its determinants during the early course of type 1 and type 2 diabetes. METHODS: Caucasian participants of the prospective German Diabetes Study (GDS) with known diabetes duration <1 year (n = 398) or without diabetes, but of similar age, body mass index (BMI) and sex distribution (n = 109), underwent measurements of flow-mediated dilation (FMD) and nitroglycerin-mediated dilatation (NMD). Whole-body insulin sensitivity (M-value) was assessed by hyperinsulinemic–euglycemic clamps and physical fitness (VO(2)max) by spiroergometry. A subset of individuals with type 1 or type 2 diabetes (n = 108) was re-evaluated after 5 years. RESULTS: At baseline, neither FMD nor NMD differed between people with diabetes and the matched glucose-tolerant groups. At the 5-year follow-up, decline in FMD (–13.9%, P = .013) of persons with type 2 diabetes was independent of age, sex, and BMI, but associated with baseline adipose tissue insulin resistance and indices of liver fibrosis. The M-value decreased in both type 1 and type 2 diabetes groups by 24% and 15% (both P < .001, respectively) over 5 years. Higher HbA1c, lower M-value, and lower VO(2)max at baseline was associated with lower FMD in both type 1 and type 2 diabetes. CONCLUSION: Endothelial function decreases during the early course of type 2 diabetes. In addition to age and BMI, insulin sensitivity at diagnosis was the best predictor of progressive impairment in endothelial function in type 2 diabetes.
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spelling pubmed-95160812022-09-29 Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes Zaharia, Oana Patricia Schön, Martin Löffler, Luca Strassburger, Klaus Möser, Clara Yurchenko, Iryna Bódis, Kálmán Antoniou, Sofia Karusheva, Yanislava Szendroedi, Julia Burkart, Volker Roden, Michael J Clin Endocrinol Metab Online Only Articles CONTEXT: Endothelial dysfunction may occur early in the development of cardiovascular and metabolic diseases; however, it remains often underestimated and studies rarely discriminate between diabetes types. We have examined endothelial function and its determinants during the early course of type 1 and type 2 diabetes. METHODS: Caucasian participants of the prospective German Diabetes Study (GDS) with known diabetes duration <1 year (n = 398) or without diabetes, but of similar age, body mass index (BMI) and sex distribution (n = 109), underwent measurements of flow-mediated dilation (FMD) and nitroglycerin-mediated dilatation (NMD). Whole-body insulin sensitivity (M-value) was assessed by hyperinsulinemic–euglycemic clamps and physical fitness (VO(2)max) by spiroergometry. A subset of individuals with type 1 or type 2 diabetes (n = 108) was re-evaluated after 5 years. RESULTS: At baseline, neither FMD nor NMD differed between people with diabetes and the matched glucose-tolerant groups. At the 5-year follow-up, decline in FMD (–13.9%, P = .013) of persons with type 2 diabetes was independent of age, sex, and BMI, but associated with baseline adipose tissue insulin resistance and indices of liver fibrosis. The M-value decreased in both type 1 and type 2 diabetes groups by 24% and 15% (both P < .001, respectively) over 5 years. Higher HbA1c, lower M-value, and lower VO(2)max at baseline was associated with lower FMD in both type 1 and type 2 diabetes. CONCLUSION: Endothelial function decreases during the early course of type 2 diabetes. In addition to age and BMI, insulin sensitivity at diagnosis was the best predictor of progressive impairment in endothelial function in type 2 diabetes. Oxford University Press 2022-08-15 /pmc/articles/PMC9516081/ /pubmed/35965389 http://dx.doi.org/10.1210/clinem/dgac480 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Online Only Articles
Zaharia, Oana Patricia
Schön, Martin
Löffler, Luca
Strassburger, Klaus
Möser, Clara
Yurchenko, Iryna
Bódis, Kálmán
Antoniou, Sofia
Karusheva, Yanislava
Szendroedi, Julia
Burkart, Volker
Roden, Michael
Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes
title Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes
title_full Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes
title_fullStr Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes
title_full_unstemmed Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes
title_short Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes
title_sort metabolic factors predict changes in endothelial function during the early course of type 1 and type 2 diabetes
topic Online Only Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516081/
https://www.ncbi.nlm.nih.gov/pubmed/35965389
http://dx.doi.org/10.1210/clinem/dgac480
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