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Multiplexed strategies toward clinical translation of extracellular vesicles
Extracellular vesicles (EVs), of which exosomes are a representative subgroup, are naturally secreted nanoparticles with a variety of payloads. With the intrinsic merits of stability, biocompatibility, low immunogenicity, and large capacity, EVs are widely regarded as effective carriers of drug deli...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516239/ https://www.ncbi.nlm.nih.gov/pubmed/36185609 http://dx.doi.org/10.7150/thno.75899 |
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author | Song, Junying Song, Baoqiang Yuan, Lijun Yang, Guodong |
author_facet | Song, Junying Song, Baoqiang Yuan, Lijun Yang, Guodong |
author_sort | Song, Junying |
collection | PubMed |
description | Extracellular vesicles (EVs), of which exosomes are a representative subgroup, are naturally secreted nanoparticles with a variety of payloads. With the intrinsic merits of stability, biocompatibility, low immunogenicity, and large capacity, EVs are widely regarded as effective carriers of drug delivery. However, disadvantages, such as low yield, complicated isolation procedures, and low loading efficiency, hinder its clinical translation. In this review, we systematically summarize the advances in EV (especially exosomes) engineering for clinical application, focusing on strategies toward high yield, facile isolation, efficient cargo loading, improved delivery, and optimized manufacturing, which might unleash the infinite power of EVs in clinical translation. |
format | Online Article Text |
id | pubmed-9516239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-95162392022-09-30 Multiplexed strategies toward clinical translation of extracellular vesicles Song, Junying Song, Baoqiang Yuan, Lijun Yang, Guodong Theranostics Review Extracellular vesicles (EVs), of which exosomes are a representative subgroup, are naturally secreted nanoparticles with a variety of payloads. With the intrinsic merits of stability, biocompatibility, low immunogenicity, and large capacity, EVs are widely regarded as effective carriers of drug delivery. However, disadvantages, such as low yield, complicated isolation procedures, and low loading efficiency, hinder its clinical translation. In this review, we systematically summarize the advances in EV (especially exosomes) engineering for clinical application, focusing on strategies toward high yield, facile isolation, efficient cargo loading, improved delivery, and optimized manufacturing, which might unleash the infinite power of EVs in clinical translation. Ivyspring International Publisher 2022-09-21 /pmc/articles/PMC9516239/ /pubmed/36185609 http://dx.doi.org/10.7150/thno.75899 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Song, Junying Song, Baoqiang Yuan, Lijun Yang, Guodong Multiplexed strategies toward clinical translation of extracellular vesicles |
title | Multiplexed strategies toward clinical translation of extracellular vesicles |
title_full | Multiplexed strategies toward clinical translation of extracellular vesicles |
title_fullStr | Multiplexed strategies toward clinical translation of extracellular vesicles |
title_full_unstemmed | Multiplexed strategies toward clinical translation of extracellular vesicles |
title_short | Multiplexed strategies toward clinical translation of extracellular vesicles |
title_sort | multiplexed strategies toward clinical translation of extracellular vesicles |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516239/ https://www.ncbi.nlm.nih.gov/pubmed/36185609 http://dx.doi.org/10.7150/thno.75899 |
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