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Multiplexed strategies toward clinical translation of extracellular vesicles

Extracellular vesicles (EVs), of which exosomes are a representative subgroup, are naturally secreted nanoparticles with a variety of payloads. With the intrinsic merits of stability, biocompatibility, low immunogenicity, and large capacity, EVs are widely regarded as effective carriers of drug deli...

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Detalles Bibliográficos
Autores principales: Song, Junying, Song, Baoqiang, Yuan, Lijun, Yang, Guodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516239/
https://www.ncbi.nlm.nih.gov/pubmed/36185609
http://dx.doi.org/10.7150/thno.75899
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author Song, Junying
Song, Baoqiang
Yuan, Lijun
Yang, Guodong
author_facet Song, Junying
Song, Baoqiang
Yuan, Lijun
Yang, Guodong
author_sort Song, Junying
collection PubMed
description Extracellular vesicles (EVs), of which exosomes are a representative subgroup, are naturally secreted nanoparticles with a variety of payloads. With the intrinsic merits of stability, biocompatibility, low immunogenicity, and large capacity, EVs are widely regarded as effective carriers of drug delivery. However, disadvantages, such as low yield, complicated isolation procedures, and low loading efficiency, hinder its clinical translation. In this review, we systematically summarize the advances in EV (especially exosomes) engineering for clinical application, focusing on strategies toward high yield, facile isolation, efficient cargo loading, improved delivery, and optimized manufacturing, which might unleash the infinite power of EVs in clinical translation.
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spelling pubmed-95162392022-09-30 Multiplexed strategies toward clinical translation of extracellular vesicles Song, Junying Song, Baoqiang Yuan, Lijun Yang, Guodong Theranostics Review Extracellular vesicles (EVs), of which exosomes are a representative subgroup, are naturally secreted nanoparticles with a variety of payloads. With the intrinsic merits of stability, biocompatibility, low immunogenicity, and large capacity, EVs are widely regarded as effective carriers of drug delivery. However, disadvantages, such as low yield, complicated isolation procedures, and low loading efficiency, hinder its clinical translation. In this review, we systematically summarize the advances in EV (especially exosomes) engineering for clinical application, focusing on strategies toward high yield, facile isolation, efficient cargo loading, improved delivery, and optimized manufacturing, which might unleash the infinite power of EVs in clinical translation. Ivyspring International Publisher 2022-09-21 /pmc/articles/PMC9516239/ /pubmed/36185609 http://dx.doi.org/10.7150/thno.75899 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Song, Junying
Song, Baoqiang
Yuan, Lijun
Yang, Guodong
Multiplexed strategies toward clinical translation of extracellular vesicles
title Multiplexed strategies toward clinical translation of extracellular vesicles
title_full Multiplexed strategies toward clinical translation of extracellular vesicles
title_fullStr Multiplexed strategies toward clinical translation of extracellular vesicles
title_full_unstemmed Multiplexed strategies toward clinical translation of extracellular vesicles
title_short Multiplexed strategies toward clinical translation of extracellular vesicles
title_sort multiplexed strategies toward clinical translation of extracellular vesicles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516239/
https://www.ncbi.nlm.nih.gov/pubmed/36185609
http://dx.doi.org/10.7150/thno.75899
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