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Loss of secreted gelsolin enhances response to anticancer therapies

Type 1 conventional dendritic cells (cDC1) play a critical role in priming anticancer cytotoxic CD8(+) T cells. DNGR-1 (a.k.a. CLEC9A) is a cDC1 receptor that binds to F-actin exposed on necrotic cancer and normal cells. DNGR-1 signaling enhances cross-presentation of dead-cell associated antigens,...

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Detalles Bibliográficos
Autores principales:	Lim, Kok Haw Jonathan, Giampazolias, Evangelos, Schulz, Oliver, Rogers, Neil C, Wilkins, Anna, Sahai, Erik, Strid, Jessica, Reis e Sousa, Caetano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516286/ https://www.ncbi.nlm.nih.gov/pubmed/36162919 http://dx.doi.org/10.1136/jitc-2022-005245

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