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Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia

BACKGROUND: Chimeric antigen receptor (CAR)-T cells have emerged as a breakthrough treatment for relapse/refractory hematological tumors, showing impressive complete remission rates. However, around 50% of the patients relapse before 1-year post-treatment. T-cell ‘fitness’ is critical to prolong CAR...

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Detalles Bibliográficos
Autores principales:	Sánchez Martínez, Diego, Tirado, Néstor, Mensurado, Sofia, Martínez-Moreno, Alba, Romecín, Paola, Gutiérrez Agüera, Francisco, Correia, Daniel V, Silva-Santos, Bruno, Menéndez, Pablo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516293/ https://www.ncbi.nlm.nih.gov/pubmed/36162920 http://dx.doi.org/10.1136/jitc-2022-005400

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