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Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis

OBJECTIVES: IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder with heterogeneous manifestations. This study aimed to investigate the utility of human epididymis protein 4 (HE4) as a potential clinical biomarker of fibrosis in IgG4-RD. METHODS: Plasma HE4 levels were est...

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Autores principales: Yan, Songxin, Peng, Yu, Wu, Ziyan, Lu, Hui, Mo, Shengwei, Chen, Xianlong, Huang, Yuan, Li, Xiaomeng, Zhang, Wen, Li, Yongzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516297/
https://www.ncbi.nlm.nih.gov/pubmed/36167476
http://dx.doi.org/10.1136/rmdopen-2022-002521
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author Yan, Songxin
Peng, Yu
Wu, Ziyan
Lu, Hui
Mo, Shengwei
Chen, Xianlong
Huang, Yuan
Li, Xiaomeng
Zhang, Wen
Li, Yongzhe
author_facet Yan, Songxin
Peng, Yu
Wu, Ziyan
Lu, Hui
Mo, Shengwei
Chen, Xianlong
Huang, Yuan
Li, Xiaomeng
Zhang, Wen
Li, Yongzhe
author_sort Yan, Songxin
collection PubMed
description OBJECTIVES: IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder with heterogeneous manifestations. This study aimed to investigate the utility of human epididymis protein 4 (HE4) as a potential clinical biomarker of fibrosis in IgG4-RD. METHODS: Plasma HE4 levels were estimated in 136 patients with IgG4-RD and 73 healthy individuals (controls) by electrochemical luminescence. HE4 expression levels and the degree of fibrosis in pancreatic tissues from 15 patients with IgG4-RD and 10 controls were compared using immunohistochemistry and Masson trichrome staining. Correlation between HE4 levels and laboratory parameters was determined, and the efficacy of HE4 as a biomarker of fibrosis and prognosis in IgG4-RD was also evaluated. RESULTS: Plasma HE4 levels were significantly higher in patients with IgG4-RD compared with controls. Optimal HE4 cut-off value for identifying patients with IgG4-RD was determined to be 50.8 pmol/L with an AUC (area under curve) of 0.791. HE4 levels were positively correlated with diverse laboratory parameters, and indicators of organ function impairment. Additionally, HE4 was highly expressed in the affected organs in patients with IgG4-RD and its plasma levels were closely correlated with degree of fibrosis, indicating the utility of HE4 in assessing internal organ damage and fibrosis. Further analysis showed that patients in the HE4 high expression group had poor prognosis. CONCLUSIONS: Our results demonstrate that HE4 can be used as a biomarker for IgG4-RD as it is correlated with diverse baseline clinical features, internal organ damage and degree of fibrosis in affected organs, and can predict poor prognosis.
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spelling pubmed-95162972022-09-29 Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis Yan, Songxin Peng, Yu Wu, Ziyan Lu, Hui Mo, Shengwei Chen, Xianlong Huang, Yuan Li, Xiaomeng Zhang, Wen Li, Yongzhe RMD Open Autoimmunity OBJECTIVES: IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder with heterogeneous manifestations. This study aimed to investigate the utility of human epididymis protein 4 (HE4) as a potential clinical biomarker of fibrosis in IgG4-RD. METHODS: Plasma HE4 levels were estimated in 136 patients with IgG4-RD and 73 healthy individuals (controls) by electrochemical luminescence. HE4 expression levels and the degree of fibrosis in pancreatic tissues from 15 patients with IgG4-RD and 10 controls were compared using immunohistochemistry and Masson trichrome staining. Correlation between HE4 levels and laboratory parameters was determined, and the efficacy of HE4 as a biomarker of fibrosis and prognosis in IgG4-RD was also evaluated. RESULTS: Plasma HE4 levels were significantly higher in patients with IgG4-RD compared with controls. Optimal HE4 cut-off value for identifying patients with IgG4-RD was determined to be 50.8 pmol/L with an AUC (area under curve) of 0.791. HE4 levels were positively correlated with diverse laboratory parameters, and indicators of organ function impairment. Additionally, HE4 was highly expressed in the affected organs in patients with IgG4-RD and its plasma levels were closely correlated with degree of fibrosis, indicating the utility of HE4 in assessing internal organ damage and fibrosis. Further analysis showed that patients in the HE4 high expression group had poor prognosis. CONCLUSIONS: Our results demonstrate that HE4 can be used as a biomarker for IgG4-RD as it is correlated with diverse baseline clinical features, internal organ damage and degree of fibrosis in affected organs, and can predict poor prognosis. BMJ Publishing Group 2022-09-27 /pmc/articles/PMC9516297/ /pubmed/36167476 http://dx.doi.org/10.1136/rmdopen-2022-002521 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Autoimmunity
Yan, Songxin
Peng, Yu
Wu, Ziyan
Lu, Hui
Mo, Shengwei
Chen, Xianlong
Huang, Yuan
Li, Xiaomeng
Zhang, Wen
Li, Yongzhe
Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis
title Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis
title_full Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis
title_fullStr Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis
title_full_unstemmed Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis
title_short Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis
title_sort human epididymis protein 4 (he4) is a novel biomarker for fibrosis in igg4-related disease and can predict poor prognosis
topic Autoimmunity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516297/
https://www.ncbi.nlm.nih.gov/pubmed/36167476
http://dx.doi.org/10.1136/rmdopen-2022-002521
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