Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons

Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. However, the mislocalization and cytoplasmic aggregation of SFPQ are associated with the pathophysiology of...

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Detalles Bibliográficos
Autores principales: Widagdo, Jocelyn, Udagedara, Saumya, Bhembre, Nishita, Tan, Jing Zhi Anson, Neureiter, Lara, Huang, Jie, Anggono, Victor, Lee, Mihwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516340/
https://www.ncbi.nlm.nih.gov/pubmed/36168806
http://dx.doi.org/10.1098/rsob.220187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516340/
https://www.ncbi.nlm.nih.gov/pubmed/36168806
http://dx.doi.org/10.1098/rsob.220187

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