Cargando…

Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons

Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. However, the mislocalization and cytoplasmic aggregation of SFPQ are associated with the pathophysiology of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Widagdo, Jocelyn, Udagedara, Saumya, Bhembre, Nishita, Tan, Jing Zhi Anson, Neureiter, Lara, Huang, Jie, Anggono, Victor, Lee, Mihwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516340/ https://www.ncbi.nlm.nih.gov/pubmed/36168806 http://dx.doi.org/10.1098/rsob.220187

Ejemplares similares

Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ
por: Huang, Jie, et al.
Publicado: (2020)

The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration
por: Lim, Yee Wa, et al.
Publicado: (2020)

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
por: Luisier, Raphaelle, et al.
Publicado: (2018)

Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease
por: Ke, Yazi, et al.
Publicado: (2012)

The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation
por: Lee, Mihwa, et al.
Publicado: (2015)

The FUS about SFPQ in FTLD spectrum disorders
por: Patani, Rickie
Publicado: (2020)

SFPQ promotes an oncogenic transcriptomic state in melanoma
por: Bi, O., et al.
Publicado: (2021)

Correction: Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease
por: Ke, Yazi, et al.
Publicado: (2012)

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability
por: Petti, Eleonora, et al.
Publicado: (2019)

SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer’s disease
por: Younas, Neelam, et al.
Publicado: (2020)

Molecular Modelling of NONO and SFPQ Dimerization Process and RNA Recognition Mechanism
por: Laurenzi, Tommaso, et al.
Publicado: (2022)

A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons
por: Gordon, Patricia M., et al.
Publicado: (2021)

The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold
por: Knott, Gavin J., et al.
Publicado: (2016)

Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq
por: Bottini, Silvia, et al.
Publicado: (2017)

The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability
por: Cosker, Katharina E, et al.
Publicado: (2016)

SFPQ, a multifunctional nuclear protein, regulates the transcription of PDE3A
por: Rhee, Dong Keun, et al.
Publicado: (2017)

Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicing
por: Mora Gallardo, Carmen, et al.
Publicado: (2019)

SFPQ and Its Isoform as Potential Biomarker for Non-Small-Cell Lung Cancer
por: Yang, Libang, et al.
Publicado: (2023)

Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex
por: Ji, Q, et al.
Publicado: (2014)

Identification of SFPQ as novel interacting partner of HIV-1 Integrase and its functional characterization
por: Sur, Souvik, et al.
Publicado: (2012)

The Splicing Factor Proline-Glutamine Rich (SFPQ/PSF) Is Involved in Influenza Virus Transcription
por: Landeras-Bueno, Sara, et al.
Publicado: (2011)

LncRNA‐422 suppresses the proliferation and growth of colorectal cancer cells by targeting SFPQ
por: Meng, Yixuan, et al.
Publicado: (2022)

Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS
por: Taylor, Richard, et al.
Publicado: (2022)

MicroRNA-1296 Facilitates Proliferation, Migration And Invasion Of Colorectal Cancer Cells By Targeting SFPQ
por: Tao, Youmao, et al.
Publicado: (2018)

NEAT1_2–SFPQ axis mediates cisplatin resistance in liver cancer cells in vitro
por: Ru, Yi, et al.
Publicado: (2018)

SFPQ Promotes Lung Cancer Malignancy via Regulation of CD44 v6 Expression
por: Yang, Libang, et al.
Publicado: (2022)

Circular RNAs arising from synaptic host genes during human neuronal differentiation are modulated by SFPQ RNA-binding protein
por: Watts, Michelle E., et al.
Publicado: (2023)

Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development
por: Thomas-Jinu, Swapna, et al.
Publicado: (2017)

Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development
por: Thomas-Jinu, Swapna, et al.
Publicado: (2017)

Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ
por: Iida, Kei, et al.
Publicado: (2020)

The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals
por: Stagsted, Lotte Victoria Winther, et al.
Publicado: (2021)

SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells
por: Kumar, Parameet, et al.
Publicado: (2021)

LncRNA NEAT1 Recruits SFPQ to Regulate MITF Splicing and Control RPE Cell Proliferation
por: Hu, Xiaojuan, et al.
Publicado: (2021)

P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis
por: Li, Yuanli, et al.
Publicado: (2023)

Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival
por: Fukuda, Yusuke, et al.
Publicado: (2020)

Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA
por: Snijders, Ambrosius P., et al.
Publicado: (2015)

Primary Xp11 translocation PEComa of the testis with SFPQ⁃TFE3 rearrangement: a case report and review of the literature
por: Zhang, Huizhi, et al.
Publicado: (2023)

Splicing factor proline- and glutamine-rich (SFPQ) protein regulates platinum response in ovarian cancer-modulating SRSF2 activity
por: Pellarin, Ilenia, et al.
Publicado: (2020)

SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72
por: Malnar, Mirjana, et al.
Publicado: (2021)

SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia
por: Brown, Lauren M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_evocibs50kri9oi876bd43ovus