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Copper-catalyzed [3+3] annulation of ketones with oxime acetates for the synthesis of pyridines
A novel and efficient copper-catalyzed strategy for the synthesis of diverse pyridines through the [3+3] annulation of ketones with oxime acetates has been reported. It is very convenient to obtain various unsymmetrical 2,6-diarylpyridines by changing different substrates. The rare copper-catalyzed...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516370/ https://www.ncbi.nlm.nih.gov/pubmed/36276018 http://dx.doi.org/10.1039/d2ra05050a |
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author | Li, Yilin Yang, Kai Cao, Liang |
author_facet | Li, Yilin Yang, Kai Cao, Liang |
author_sort | Li, Yilin |
collection | PubMed |
description | A novel and efficient copper-catalyzed strategy for the synthesis of diverse pyridines through the [3+3] annulation of ketones with oxime acetates has been reported. It is very convenient to obtain various unsymmetrical 2,6-diarylpyridines by changing different substrates. The rare copper-catalyzed direct difunctionalization of saturated ketones for the synthesis of nitrogen heterocycles is developed. This protocol has excellent functional group tolerance, readily available raw materials, high chemoselectivity and broad substrate scope. |
format | Online Article Text |
id | pubmed-9516370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-95163702022-10-21 Copper-catalyzed [3+3] annulation of ketones with oxime acetates for the synthesis of pyridines Li, Yilin Yang, Kai Cao, Liang RSC Adv Chemistry A novel and efficient copper-catalyzed strategy for the synthesis of diverse pyridines through the [3+3] annulation of ketones with oxime acetates has been reported. It is very convenient to obtain various unsymmetrical 2,6-diarylpyridines by changing different substrates. The rare copper-catalyzed direct difunctionalization of saturated ketones for the synthesis of nitrogen heterocycles is developed. This protocol has excellent functional group tolerance, readily available raw materials, high chemoselectivity and broad substrate scope. The Royal Society of Chemistry 2022-09-28 /pmc/articles/PMC9516370/ /pubmed/36276018 http://dx.doi.org/10.1039/d2ra05050a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Li, Yilin Yang, Kai Cao, Liang Copper-catalyzed [3+3] annulation of ketones with oxime acetates for the synthesis of pyridines |
title | Copper-catalyzed [3+3] annulation of ketones with oxime acetates for the synthesis of pyridines |
title_full | Copper-catalyzed [3+3] annulation of ketones with oxime acetates for the synthesis of pyridines |
title_fullStr | Copper-catalyzed [3+3] annulation of ketones with oxime acetates for the synthesis of pyridines |
title_full_unstemmed | Copper-catalyzed [3+3] annulation of ketones with oxime acetates for the synthesis of pyridines |
title_short | Copper-catalyzed [3+3] annulation of ketones with oxime acetates for the synthesis of pyridines |
title_sort | copper-catalyzed [3+3] annulation of ketones with oxime acetates for the synthesis of pyridines |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516370/ https://www.ncbi.nlm.nih.gov/pubmed/36276018 http://dx.doi.org/10.1039/d2ra05050a |
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