Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations

KRAS is the most commonly mutated oncogene in human cancers with limited therapeutic options, thus there is a critical need to identify novel targets and inhibiting agents. The 78-kDa glucose-regulated protein GRP78, which is upregulated in KRAS cancers, is an essential chaperone and the master regu...

Descripción completa

Detalles Bibliográficos
Autores principales: Ha, Dat P., Huang, Bo, Wang, Han, Rangel, Daisy Flores, Van Krieken, Richard, Liu, Ze, Samanta, Soma, Neamati, Nouri, Lee, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516447/
https://www.ncbi.nlm.nih.gov/pubmed/36162331
http://dx.doi.org/10.1016/j.neo.2022.100837

Ejemplares similares

Ejemplares similares