Cargando…

Positive epigenetic regulation loop between AR and NSUN2 promotes prostate cancer progression

BACKGROUND: Prostate cancer (PCa) is a major type of cancer in man worldwide. Androgen deprivation therapy (ADT) and the next‐generation androgen receptor (AR) pathway inhibitors have acquired great success in treating PCa. However, patients treated with ADT or AR targeted therapy are inevitably dev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Wenkai, Wan, Fangning, Xu, Wenhao, Liu, Zheng, Wang, Junjie, Zhang, Hena, Huang, Shenglin, Ye, Dingwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516604/ https://www.ncbi.nlm.nih.gov/pubmed/36169095 http://dx.doi.org/10.1002/ctm2.1028

Ejemplares similares

GABARAPL1 Promotes AR+ Prostate Cancer Growth by Increasing FL-AR/AR-V Transcription Activity and Nuclear Translocation
por: Su, Bing, et al.
Publicado: (2019)

NSUN5 promotes progression and predicts poor prognosis in hepatocellular carcinoma
por: Zhang, Xiao-Wen, et al.
Publicado: (2022)

NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma
por: Tong, Xinya, et al.
Publicado: (2022)

NSun2 promotes cell migration through methylating autotaxin mRNA
por: Xu, Xin, et al.
Publicado: (2021)

Development and validation of lncRNAs-based nomogram for prediction of biochemical recurrence in prostate cancer by bioinformatics analysis
por: Shao, Ning, et al.
Publicado: (2019)

A novel gene signature to predict immune infiltration and outcome in patients with prostate cancer
por: Shao, Ning, et al.
Publicado: (2020)

Multi-omics analysis of expression and prognostic value of NSUN members in prostate cancer
por: Sun, Guangyu, et al.
Publicado: (2022)

Constitutively Active AR-V7 Plays an Essential Role in the Development and Progression of Castration-Resistant Prostate Cancer
por: Qu, Yuanyuan, et al.
Publicado: (2015)

RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence
por: Cai, Xiaoyu, et al.
Publicado: (2016)

The HIF/PHF8/AR axis promotes prostate cancer progression
por: Tong, D, et al.
Publicado: (2016)

m(6)A Regulator-Mediated Methylation Modification Model Predicts Prognosis, Tumor Microenvironment Characterizations and Response to Immunotherapies of Clear Cell Renal Cell Carcinoma
por: Xu, Wenhao, et al.
Publicado: (2021)

ACK1–AR and AR–HOXB13 signaling axes: epigenetic regulation of lethal prostate cancers
por: Kim, Eric H, et al.
Publicado: (2020)

Conditional Survival in Patients with Advanced Renal Cell Carcinoma Treated with Nivolumab
por: Shao, Ning, et al.
Publicado: (2019)

IRE1α Expedites the Progression of Castration-Resistant Prostate Cancers via the Positive Feedback Loop of IRE1α/IL-6/AR
por: Yang, Fan, et al.
Publicado: (2021)

Reorganization of the Landscape of Translated mRNAs in NSUN2-Deficient Cells and Specific Features of NSUN2 Target mRNAs
por: Kossinova, Olga A., et al.
Publicado: (2022)

Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer
por: Yi, Jie, et al.
Publicado: (2016)

Fatty Acid Synthase Correlates With Prognosis-Related Abdominal Adipose Distribution and Metabolic Disorders of Clear Cell Renal Cell Carcinoma
por: Xu, Wenhao, et al.
Publicado: (2021)

Differential expression of m(5)C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and traumatic brain injury
por: PerezGrovas-Saltijeral, Adriana, et al.
Publicado: (2023)

NSUN2‐mediated m(5)C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression
por: Zuo, Sipeng, et al.
Publicado: (2023)

M6A modification of circNSUN2 promotes colorectal liver metastasis
por: He, Rong-Zhang, et al.
Publicado: (2019)

RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma
por: Zhou, Jiesi, et al.
Publicado: (2023)

NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m(5)C methylation
por: Yang, Min, et al.
Publicado: (2023)

Prognostic value of D-lactate dehydrogenase in patients with clear cell renal cell carcinoma
por: Wang, Yue, et al.
Publicado: (2018)

Prognostic significance of the dynamic changes of systemic inflammatory response in metastatic renal cell carcinoma
por: Wang, Beihe, et al.
Publicado: (2019)

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program
por: Janin, Maxime, et al.
Publicado: (2019)

Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
por: Ortiz-Barahona, Vanessa, et al.
Publicado: (2023)

Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation
por: Yang, Lin, et al.
Publicado: (2022)

NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation
por: Hu, Yuanbo, et al.
Publicado: (2021)

CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4
por: Qi, Mei, et al.
Publicado: (2019)

RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation
por: Kim, Yoon A., et al.
Publicado: (2022)

The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer
por: Chellamuthu, Anitha, et al.
Publicado: (2020)

OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR
por: Fu, Xuhong, et al.
Publicado: (2022)

Causes of Death and Conditional Survival of Renal Cell Carcinoma
por: Shao, Ning, et al.
Publicado: (2019)

Baicalein suppresses the androgen receptor (AR)-mediated prostate cancer progression via inhibiting the AR N-C dimerization and AR-coactivators interaction
por: Xu, Defeng, et al.
Publicado: (2017)

RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity
por: Trixl, Lukas, et al.
Publicado: (2017)

Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis
por: Yang, Wen-Lan, et al.
Publicado: (2023)

NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer
por: Zhang, Guizhen, et al.
Publicado: (2023)

Expression of the RNA methyltransferase Nsun5 is essential for developing cerebral cortex
por: Chen, Peipei, et al.
Publicado: (2019)

Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs
por: Shinoda, Saori, et al.
Publicado: (2019)

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs
por: Van Haute, Lindsey, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_scul14rlct8tc0s7ja8pcl4agc