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The DNA repair function of BCL11A suppresses senescence and promotes continued proliferation of triple-negative breast cancer cells
We identified the BCL11A protein in a proximity-dependent biotinylation screen performed with the DNA glycosylase NTHL1. In vitro, DNA repair assays demonstrate that both BCL11A and a small recombinant BCL11A(160–520) protein that is devoid of DNA binding and transcription regulatory domains can sti...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516615/ https://www.ncbi.nlm.nih.gov/pubmed/36186110 http://dx.doi.org/10.1093/narcan/zcac028 |