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Low protein diet supplemented with ketoacids on muscle wasting in chronic kidney disease: A clinical trial

AIM: Nutrition is an important part of the care of patients with chronic kidney disease (CKD). However, there is limited clinical research on the skeletal muscle nutrition of patients with CKD. We carried out this study to find out whether a low-protein diet supplemented with ketoacids (LPD + KA) co...

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Autores principales: Zhang, Yueyue, Gu, Lijie, Wang, Ling, Rong, Shu, Yuan, Weijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516635/
https://www.ncbi.nlm.nih.gov/pubmed/36186800
http://dx.doi.org/10.3389/fmed.2022.949108
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author Zhang, Yueyue
Gu, Lijie
Wang, Ling
Rong, Shu
Yuan, Weijie
author_facet Zhang, Yueyue
Gu, Lijie
Wang, Ling
Rong, Shu
Yuan, Weijie
author_sort Zhang, Yueyue
collection PubMed
description AIM: Nutrition is an important part of the care of patients with chronic kidney disease (CKD). However, there is limited clinical research on the skeletal muscle nutrition of patients with CKD. We carried out this study to find out whether a low-protein diet supplemented with ketoacids (LPD + KA) could improve muscle wasting in patients with CKD. METHODS: Patients were enrolled in this non-blind, parallel-group, randomized trial assessing the nutritional status of CKD, randomly assigned to either the LPD + KA group or conventional LPD group. Blood samples such as Hemoglobin, Cystatin C, Creatinine, BUN, Albumin, Pre- Albumin, Glycerin Trilaurate, and Cholesterol were measured at baseline and every 3 months. The parameters of skeletal muscle and other body composition were assessed before and after dietary intervention for 12 months. RESULTS: A total of 58 patients with CKD completed the study and were available for further analysis. The hemoglobin and albumin were observed to be markedly improved in the LPD + KA group during the follow-up as compared to baseline. Body mass index and total body water index of both groups were increased upon follow-up but the increase in the LPD + KA group was comparatively higher. Moreover, an increase in body fat%, skeletal muscle mass index, and appendicular skeletal muscle mass index was observed in both groups between baseline and follow-up, but it was statistically insignificant. CONCLUSION: This study did not find a significant improvement of KAs on muscle wasting, and a long time or more indices study may need to find the effects of the LPD + KA diets. CLINICAL TRIAL REGISTRATION: [www.ClinicalTrials.gov], identifier [NCT02568020].
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spelling pubmed-95166352022-09-29 Low protein diet supplemented with ketoacids on muscle wasting in chronic kidney disease: A clinical trial Zhang, Yueyue Gu, Lijie Wang, Ling Rong, Shu Yuan, Weijie Front Med (Lausanne) Medicine AIM: Nutrition is an important part of the care of patients with chronic kidney disease (CKD). However, there is limited clinical research on the skeletal muscle nutrition of patients with CKD. We carried out this study to find out whether a low-protein diet supplemented with ketoacids (LPD + KA) could improve muscle wasting in patients with CKD. METHODS: Patients were enrolled in this non-blind, parallel-group, randomized trial assessing the nutritional status of CKD, randomly assigned to either the LPD + KA group or conventional LPD group. Blood samples such as Hemoglobin, Cystatin C, Creatinine, BUN, Albumin, Pre- Albumin, Glycerin Trilaurate, and Cholesterol were measured at baseline and every 3 months. The parameters of skeletal muscle and other body composition were assessed before and after dietary intervention for 12 months. RESULTS: A total of 58 patients with CKD completed the study and were available for further analysis. The hemoglobin and albumin were observed to be markedly improved in the LPD + KA group during the follow-up as compared to baseline. Body mass index and total body water index of both groups were increased upon follow-up but the increase in the LPD + KA group was comparatively higher. Moreover, an increase in body fat%, skeletal muscle mass index, and appendicular skeletal muscle mass index was observed in both groups between baseline and follow-up, but it was statistically insignificant. CONCLUSION: This study did not find a significant improvement of KAs on muscle wasting, and a long time or more indices study may need to find the effects of the LPD + KA diets. CLINICAL TRIAL REGISTRATION: [www.ClinicalTrials.gov], identifier [NCT02568020]. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9516635/ /pubmed/36186800 http://dx.doi.org/10.3389/fmed.2022.949108 Text en Copyright © 2022 Zhang, Gu, Wang, Rong and Yuan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhang, Yueyue
Gu, Lijie
Wang, Ling
Rong, Shu
Yuan, Weijie
Low protein diet supplemented with ketoacids on muscle wasting in chronic kidney disease: A clinical trial
title Low protein diet supplemented with ketoacids on muscle wasting in chronic kidney disease: A clinical trial
title_full Low protein diet supplemented with ketoacids on muscle wasting in chronic kidney disease: A clinical trial
title_fullStr Low protein diet supplemented with ketoacids on muscle wasting in chronic kidney disease: A clinical trial
title_full_unstemmed Low protein diet supplemented with ketoacids on muscle wasting in chronic kidney disease: A clinical trial
title_short Low protein diet supplemented with ketoacids on muscle wasting in chronic kidney disease: A clinical trial
title_sort low protein diet supplemented with ketoacids on muscle wasting in chronic kidney disease: a clinical trial
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516635/
https://www.ncbi.nlm.nih.gov/pubmed/36186800
http://dx.doi.org/10.3389/fmed.2022.949108
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