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Inverse relations between Helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption

BACKGROUND: Helicobacter pylori (H. pylori) is a Gram-negative bacterium found in the upper digestive tract. Although H. pylori infection is an identified risk factor for gastric cancer, its role in esophageal squamous cell carcinoma (ESCC) remains a topic of much debate. AIM: To evaluate the associ...

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Autores principales: Pan, Da, Sun, Gui-Ju, Su, Ming, Wang, Xin, Yan, Qing-Yang, Song, Guang, Wang, Yuan-Yuan, Xu, Deng-Feng, Wang, Nian-Nian, Wang, Shao-Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516658/
https://www.ncbi.nlm.nih.gov/pubmed/36187387
http://dx.doi.org/10.4251/wjgo.v14.i9.1689
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author Pan, Da
Sun, Gui-Ju
Su, Ming
Wang, Xin
Yan, Qing-Yang
Song, Guang
Wang, Yuan-Yuan
Xu, Deng-Feng
Wang, Nian-Nian
Wang, Shao-Kang
author_facet Pan, Da
Sun, Gui-Ju
Su, Ming
Wang, Xin
Yan, Qing-Yang
Song, Guang
Wang, Yuan-Yuan
Xu, Deng-Feng
Wang, Nian-Nian
Wang, Shao-Kang
author_sort Pan, Da
collection PubMed
description BACKGROUND: Helicobacter pylori (H. pylori) is a Gram-negative bacterium found in the upper digestive tract. Although H. pylori infection is an identified risk factor for gastric cancer, its role in esophageal squamous cell carcinoma (ESCC) remains a topic of much debate. AIM: To evaluate the association between H. pylori infection and the risk of precancerous lesions of ESCC, and further explore the association between dietary factors and the risk of H. pylori infection. METHODS: Two hundred patients with esophageal precancerous lesions (EPL) aged 63.01 ± 6.08 years and 200 healthy controls aged 62.85 ± 6.03 years were included in this case-control study. Epidemiological data and qualitative food frequency data were investigated. Enzyme-linked immunosorbent assay measuring serum immunoglobulin G antibodies was used to determine H. pylori seropositivity. An unconditional logistic regression model was used to assess the association between H. pylori infection and EPL risk dichotomized by gender, age, and the use of tobacco and alcohol, as well as the association between dietary factors and the risk of H. pylori infection. RESULTS: A total of 47 (23.5%) EPL cases and 58 (29.0%) healthy controls had positive H. pylori infection. An inverse relation between H. pylori infection and the risk of EPL was found in the group of drinkers after adjustment for covariates [odds ratio (OR) = 0.32, 95% confidence interval (95%CI): 0.11-0.95]. Additionally, peanut intake was significantly associated with a decreased risk of H. pylori infection (OR = 0.39, 95%CI: 0.20-0.74). CONCLUSION: Our study suggested that H. pylori infection may decrease the risk of EPL for drinkers in a rural adult Chinese population, and the consumption of peanut may reduce the risk of H. pylori infection. These findings should be framed as preliminary evidence, and further studies are required to address whether the mechanisms are related to the localization of lesions and alcohol consumption.
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spelling pubmed-95166582022-09-29 Inverse relations between Helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption Pan, Da Sun, Gui-Ju Su, Ming Wang, Xin Yan, Qing-Yang Song, Guang Wang, Yuan-Yuan Xu, Deng-Feng Wang, Nian-Nian Wang, Shao-Kang World J Gastrointest Oncol Case Control Study BACKGROUND: Helicobacter pylori (H. pylori) is a Gram-negative bacterium found in the upper digestive tract. Although H. pylori infection is an identified risk factor for gastric cancer, its role in esophageal squamous cell carcinoma (ESCC) remains a topic of much debate. AIM: To evaluate the association between H. pylori infection and the risk of precancerous lesions of ESCC, and further explore the association between dietary factors and the risk of H. pylori infection. METHODS: Two hundred patients with esophageal precancerous lesions (EPL) aged 63.01 ± 6.08 years and 200 healthy controls aged 62.85 ± 6.03 years were included in this case-control study. Epidemiological data and qualitative food frequency data were investigated. Enzyme-linked immunosorbent assay measuring serum immunoglobulin G antibodies was used to determine H. pylori seropositivity. An unconditional logistic regression model was used to assess the association between H. pylori infection and EPL risk dichotomized by gender, age, and the use of tobacco and alcohol, as well as the association between dietary factors and the risk of H. pylori infection. RESULTS: A total of 47 (23.5%) EPL cases and 58 (29.0%) healthy controls had positive H. pylori infection. An inverse relation between H. pylori infection and the risk of EPL was found in the group of drinkers after adjustment for covariates [odds ratio (OR) = 0.32, 95% confidence interval (95%CI): 0.11-0.95]. Additionally, peanut intake was significantly associated with a decreased risk of H. pylori infection (OR = 0.39, 95%CI: 0.20-0.74). CONCLUSION: Our study suggested that H. pylori infection may decrease the risk of EPL for drinkers in a rural adult Chinese population, and the consumption of peanut may reduce the risk of H. pylori infection. These findings should be framed as preliminary evidence, and further studies are required to address whether the mechanisms are related to the localization of lesions and alcohol consumption. Baishideng Publishing Group Inc 2022-09-15 2022-09-15 /pmc/articles/PMC9516658/ /pubmed/36187387 http://dx.doi.org/10.4251/wjgo.v14.i9.1689 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Control Study
Pan, Da
Sun, Gui-Ju
Su, Ming
Wang, Xin
Yan, Qing-Yang
Song, Guang
Wang, Yuan-Yuan
Xu, Deng-Feng
Wang, Nian-Nian
Wang, Shao-Kang
Inverse relations between Helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption
title Inverse relations between Helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption
title_full Inverse relations between Helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption
title_fullStr Inverse relations between Helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption
title_full_unstemmed Inverse relations between Helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption
title_short Inverse relations between Helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption
title_sort inverse relations between helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption
topic Case Control Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516658/
https://www.ncbi.nlm.nih.gov/pubmed/36187387
http://dx.doi.org/10.4251/wjgo.v14.i9.1689
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