The reversion of DNA methylation-induced miRNA silence via biomimetic nanoparticles-mediated gene delivery for efficient lung adenocarcinoma therapy

BACKGROUND: Lung cancer is one of the fatal cancers worldwide, and over 60% of patients are lung adenocarcinoma (LUAD). Our clinical data demonstrated that DNA methylation of the promoter region of miR-126-3p was upregulated, which led to the decreased expression of miR-126-3p in 67 cases of lung ca...

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Detalles Bibliográficos
Autores principales: Liang, Lu, Cen, Huiyu, Huang, Jionghua, Qin, Aiping, Xu, Wenyan, Wang, Siran, Chen, Zhijun, Tan, Lin, Zhang, Qiqi, Yu, Xiyong, Yang, Xin, Zhang, Lingmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516831/
https://www.ncbi.nlm.nih.gov/pubmed/36171576
http://dx.doi.org/10.1186/s12943-022-01651-4

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