Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium handling

BACKGROUND: Malignant ventricular arrhythmia (VA) is a major contributor to sudden cardiac death (SCD) in patients with pulmonary arterial hypertension (PAH)-induced right heart failure (RHF). Recently, dapagliflozin (DAPA), a sodium/glucose cotransporter-2 inhibitor (SGLT2i), has been found to exhi...

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Detalles Bibliográficos
Autores principales: Wu, Jinchun, Liu, Tao, Shi, Shaobo, Fan, Zhixing, Hiram, Roddy, Xiong, Feng, Cui, Bo, Su, Xiaoling, Chang, Rong, Zhang, Wei, Yan, Min, Tang, Yanhong, Huang, He, Wu, Gang, Huang, Congxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516842/
https://www.ncbi.nlm.nih.gov/pubmed/36171554
http://dx.doi.org/10.1186/s12933-022-01614-5

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