Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

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Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CL(pro)) encoded by diverse coronaviruses, including SARS-CoV-2, cleaves a ra...

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Detalles Bibliográficos
Autores principales: Tsu, Brian V., Agarwal, Rimjhim, Gokhale, Nandan S., Kulsuptrakul, Jessie, Ryan, Andrew P., Castro, Lennice K., Beierschmitt, Christopher M., Turcotte, Elizabeth A., Fay, Elizabeth J., Vance, Russell E., Hyde, Jennifer L., Savan, Ram, Mitchell, Patrick S., Daugherty, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516851/
https://www.ncbi.nlm.nih.gov/pubmed/36172130
http://dx.doi.org/10.1101/2022.09.21.508960
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