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Rare giant corneal keloid presenting 26 years after trauma: A case report
BACKGROUND: Corneal keloid is a rare clinical disease with an unknown etiology, which is easily misdiagnosed. Surgery is the most effective treatment but is rarely reported in the literature. Herein, we report the clinical features, histopathology, and surgical outcome of a giant corneal keloid with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516904/ https://www.ncbi.nlm.nih.gov/pubmed/36186176 http://dx.doi.org/10.12998/wjcc.v10.i27.9776 |
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author | Li, Shang Lei, Jiang Wang, Ying-Hui Xu, Xiao-Lin Yang, Ke Jie, Ying |
author_facet | Li, Shang Lei, Jiang Wang, Ying-Hui Xu, Xiao-Lin Yang, Ke Jie, Ying |
author_sort | Li, Shang |
collection | PubMed |
description | BACKGROUND: Corneal keloid is a rare clinical disease with an unknown etiology, which is easily misdiagnosed. Surgery is the most effective treatment but is rarely reported in the literature. Herein, we report the clinical features, histopathology, and surgical outcome of a giant corneal keloid with trophoblastic vessels and discuss the genesis of the mass. CASE SUMMARY: A 36-year-old young man was admitted to the hospital because of a large mass on the surface of the left cornea. The patient had suffered an injury to his left eye at the age of 6-years-old; however, as the injury did not cause cornea perforation, he did not undergo treatment. Slit lamp exam showed a large, elevated, opaque lesion that covered the entire cornea and protruded from the surface of the eyeball. Anterior segment optical coherence tomography (AS-OCT) revealed a lesion of irregular density involving the anterior stroma. We suspected a secondary corneal fibroproliferative mass based on the clinical history, and slit lamp and AS-OCT findings. The patient subsequently underwent a superficial keratectomy and keratoplasty, and the final diagnosis of corneal keloid was confirmed by intraoperative histopathological examination. CONCLUSION: Non-penetrating corneal trauma damages corneal epithelium basement membrane, initiating stromal fibrosis and causing corneal keloids. AS-OCT and biopsy confirm diagnosis. |
format | Online Article Text |
id | pubmed-9516904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-95169042022-09-29 Rare giant corneal keloid presenting 26 years after trauma: A case report Li, Shang Lei, Jiang Wang, Ying-Hui Xu, Xiao-Lin Yang, Ke Jie, Ying World J Clin Cases Case Report BACKGROUND: Corneal keloid is a rare clinical disease with an unknown etiology, which is easily misdiagnosed. Surgery is the most effective treatment but is rarely reported in the literature. Herein, we report the clinical features, histopathology, and surgical outcome of a giant corneal keloid with trophoblastic vessels and discuss the genesis of the mass. CASE SUMMARY: A 36-year-old young man was admitted to the hospital because of a large mass on the surface of the left cornea. The patient had suffered an injury to his left eye at the age of 6-years-old; however, as the injury did not cause cornea perforation, he did not undergo treatment. Slit lamp exam showed a large, elevated, opaque lesion that covered the entire cornea and protruded from the surface of the eyeball. Anterior segment optical coherence tomography (AS-OCT) revealed a lesion of irregular density involving the anterior stroma. We suspected a secondary corneal fibroproliferative mass based on the clinical history, and slit lamp and AS-OCT findings. The patient subsequently underwent a superficial keratectomy and keratoplasty, and the final diagnosis of corneal keloid was confirmed by intraoperative histopathological examination. CONCLUSION: Non-penetrating corneal trauma damages corneal epithelium basement membrane, initiating stromal fibrosis and causing corneal keloids. AS-OCT and biopsy confirm diagnosis. Baishideng Publishing Group Inc 2022-09-26 2022-09-26 /pmc/articles/PMC9516904/ /pubmed/36186176 http://dx.doi.org/10.12998/wjcc.v10.i27.9776 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Case Report Li, Shang Lei, Jiang Wang, Ying-Hui Xu, Xiao-Lin Yang, Ke Jie, Ying Rare giant corneal keloid presenting 26 years after trauma: A case report |
title | Rare giant corneal keloid presenting 26 years after trauma: A case report |
title_full | Rare giant corneal keloid presenting 26 years after trauma: A case report |
title_fullStr | Rare giant corneal keloid presenting 26 years after trauma: A case report |
title_full_unstemmed | Rare giant corneal keloid presenting 26 years after trauma: A case report |
title_short | Rare giant corneal keloid presenting 26 years after trauma: A case report |
title_sort | rare giant corneal keloid presenting 26 years after trauma: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516904/ https://www.ncbi.nlm.nih.gov/pubmed/36186176 http://dx.doi.org/10.12998/wjcc.v10.i27.9776 |
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