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Rare giant corneal keloid presenting 26 years after trauma: A case report

BACKGROUND: Corneal keloid is a rare clinical disease with an unknown etiology, which is easily misdiagnosed. Surgery is the most effective treatment but is rarely reported in the literature. Herein, we report the clinical features, histopathology, and surgical outcome of a giant corneal keloid with...

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Autores principales: Li, Shang, Lei, Jiang, Wang, Ying-Hui, Xu, Xiao-Lin, Yang, Ke, Jie, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516904/
https://www.ncbi.nlm.nih.gov/pubmed/36186176
http://dx.doi.org/10.12998/wjcc.v10.i27.9776
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author Li, Shang
Lei, Jiang
Wang, Ying-Hui
Xu, Xiao-Lin
Yang, Ke
Jie, Ying
author_facet Li, Shang
Lei, Jiang
Wang, Ying-Hui
Xu, Xiao-Lin
Yang, Ke
Jie, Ying
author_sort Li, Shang
collection PubMed
description BACKGROUND: Corneal keloid is a rare clinical disease with an unknown etiology, which is easily misdiagnosed. Surgery is the most effective treatment but is rarely reported in the literature. Herein, we report the clinical features, histopathology, and surgical outcome of a giant corneal keloid with trophoblastic vessels and discuss the genesis of the mass. CASE SUMMARY: A 36-year-old young man was admitted to the hospital because of a large mass on the surface of the left cornea. The patient had suffered an injury to his left eye at the age of 6-years-old; however, as the injury did not cause cornea perforation, he did not undergo treatment. Slit lamp exam showed a large, elevated, opaque lesion that covered the entire cornea and protruded from the surface of the eyeball. Anterior segment optical coherence tomography (AS-OCT) revealed a lesion of irregular density involving the anterior stroma. We suspected a secondary corneal fibroproliferative mass based on the clinical history, and slit lamp and AS-OCT findings. The patient subsequently underwent a superficial keratectomy and keratoplasty, and the final diagnosis of corneal keloid was confirmed by intraoperative histopathological examination. CONCLUSION: Non-penetrating corneal trauma damages corneal epithelium basement membrane, initiating stromal fibrosis and causing corneal keloids. AS-OCT and biopsy confirm diagnosis.
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spelling pubmed-95169042022-09-29 Rare giant corneal keloid presenting 26 years after trauma: A case report Li, Shang Lei, Jiang Wang, Ying-Hui Xu, Xiao-Lin Yang, Ke Jie, Ying World J Clin Cases Case Report BACKGROUND: Corneal keloid is a rare clinical disease with an unknown etiology, which is easily misdiagnosed. Surgery is the most effective treatment but is rarely reported in the literature. Herein, we report the clinical features, histopathology, and surgical outcome of a giant corneal keloid with trophoblastic vessels and discuss the genesis of the mass. CASE SUMMARY: A 36-year-old young man was admitted to the hospital because of a large mass on the surface of the left cornea. The patient had suffered an injury to his left eye at the age of 6-years-old; however, as the injury did not cause cornea perforation, he did not undergo treatment. Slit lamp exam showed a large, elevated, opaque lesion that covered the entire cornea and protruded from the surface of the eyeball. Anterior segment optical coherence tomography (AS-OCT) revealed a lesion of irregular density involving the anterior stroma. We suspected a secondary corneal fibroproliferative mass based on the clinical history, and slit lamp and AS-OCT findings. The patient subsequently underwent a superficial keratectomy and keratoplasty, and the final diagnosis of corneal keloid was confirmed by intraoperative histopathological examination. CONCLUSION: Non-penetrating corneal trauma damages corneal epithelium basement membrane, initiating stromal fibrosis and causing corneal keloids. AS-OCT and biopsy confirm diagnosis. Baishideng Publishing Group Inc 2022-09-26 2022-09-26 /pmc/articles/PMC9516904/ /pubmed/36186176 http://dx.doi.org/10.12998/wjcc.v10.i27.9776 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Report
Li, Shang
Lei, Jiang
Wang, Ying-Hui
Xu, Xiao-Lin
Yang, Ke
Jie, Ying
Rare giant corneal keloid presenting 26 years after trauma: A case report
title Rare giant corneal keloid presenting 26 years after trauma: A case report
title_full Rare giant corneal keloid presenting 26 years after trauma: A case report
title_fullStr Rare giant corneal keloid presenting 26 years after trauma: A case report
title_full_unstemmed Rare giant corneal keloid presenting 26 years after trauma: A case report
title_short Rare giant corneal keloid presenting 26 years after trauma: A case report
title_sort rare giant corneal keloid presenting 26 years after trauma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516904/
https://www.ncbi.nlm.nih.gov/pubmed/36186176
http://dx.doi.org/10.12998/wjcc.v10.i27.9776
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