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Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis
Insomnia is a common complaint affecting human performance in daily life activities. This study aimed to analyze the effects of Crocus sativus on insomnia. Methods: PRISMA guidelines were used according to the PICOS model. A systematic search of PubMed/Medline and the Cochrane Library was undertaken...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517076/ https://www.ncbi.nlm.nih.gov/pubmed/36141931 http://dx.doi.org/10.3390/ijerph191811658 |
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author | Munirah, Mohd Puad Norhayati, Mohd Noor Noraini, Mohamad |
author_facet | Munirah, Mohd Puad Norhayati, Mohd Noor Noraini, Mohamad |
author_sort | Munirah, Mohd Puad |
collection | PubMed |
description | Insomnia is a common complaint affecting human performance in daily life activities. This study aimed to analyze the effects of Crocus sativus on insomnia. Methods: PRISMA guidelines were used according to the PICOS model. A systematic search of PubMed/Medline and the Cochrane Library was undertaken for literature until December 2021. A random effects model was used with I(2) statistic to assess heterogeneity and a GRADE assessment was used to assess the quality of the outcomes. Eight articles were included, involving 431 participants. Crocus sativus reduced insomnia severity (SMD: 0.53; 95%CI: −0.05 to 1.11; I(2) statistic = 59%; p = 0.08) and increased sleep quality (SMD 0.89, 95% CI 0.10 to 1.68; I(2) statistic = 90%; p = 0.03; 6 studies, 308 participants, very low-quality evidence) and duration (SMD: 0.57; 95%CI: 0.21 to 0.93; I(2) statistic = 40%; p = 0.002; 5 studies; 220 participants, moderate-quality evidence) compared with the placebos. Although there is limited evidence of a very low- to moderate-quality, Crocus sativus may benefit people with insomnia. This non-pharmacological intervention may reduce the chance of adults with insomnia taking sedative–hypnotic medication, thus reducing dependency and withdrawal symptoms. |
format | Online Article Text |
id | pubmed-9517076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95170762022-09-29 Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis Munirah, Mohd Puad Norhayati, Mohd Noor Noraini, Mohamad Int J Environ Res Public Health Review Insomnia is a common complaint affecting human performance in daily life activities. This study aimed to analyze the effects of Crocus sativus on insomnia. Methods: PRISMA guidelines were used according to the PICOS model. A systematic search of PubMed/Medline and the Cochrane Library was undertaken for literature until December 2021. A random effects model was used with I(2) statistic to assess heterogeneity and a GRADE assessment was used to assess the quality of the outcomes. Eight articles were included, involving 431 participants. Crocus sativus reduced insomnia severity (SMD: 0.53; 95%CI: −0.05 to 1.11; I(2) statistic = 59%; p = 0.08) and increased sleep quality (SMD 0.89, 95% CI 0.10 to 1.68; I(2) statistic = 90%; p = 0.03; 6 studies, 308 participants, very low-quality evidence) and duration (SMD: 0.57; 95%CI: 0.21 to 0.93; I(2) statistic = 40%; p = 0.002; 5 studies; 220 participants, moderate-quality evidence) compared with the placebos. Although there is limited evidence of a very low- to moderate-quality, Crocus sativus may benefit people with insomnia. This non-pharmacological intervention may reduce the chance of adults with insomnia taking sedative–hypnotic medication, thus reducing dependency and withdrawal symptoms. MDPI 2022-09-16 /pmc/articles/PMC9517076/ /pubmed/36141931 http://dx.doi.org/10.3390/ijerph191811658 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Munirah, Mohd Puad Norhayati, Mohd Noor Noraini, Mohamad Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis |
title | Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis |
title_full | Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis |
title_fullStr | Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis |
title_short | Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis |
title_sort | crocus sativus for insomnia: a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517076/ https://www.ncbi.nlm.nih.gov/pubmed/36141931 http://dx.doi.org/10.3390/ijerph191811658 |
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