Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature

Gorham-Stout disease (GSD) is a very rare, life-threatening condition characterized by the proliferation of lymphatic vessels and osteolysis. Unfortunately, no standard treatment has been determined for management of GSD. The available therapies are not equally effective and carry substantial side-e...

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Detalles Bibliográficos
Autores principales: Wojciechowska-Durczynska, Katarzyna, Zygmunt, Arkadiusz, Mikulak, Marta, Ludwisiak, Marta, Lewinski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517245/
https://www.ncbi.nlm.nih.gov/pubmed/36141975
http://dx.doi.org/10.3390/ijerph191811692
Descripción
Sumario:Gorham-Stout disease (GSD) is a very rare, life-threatening condition characterized by the proliferation of lymphatic vessels and osteolysis. Unfortunately, no standard treatment has been determined for management of GSD. The available therapies are not equally effective and carry substantial side-effects. We report a 42-year-old female with GSD manifested in multifocal osteolysis and chronic chylothorax and ascites. The combined treatment with sirolimus and zoledronic acid due to its synergism of action was introduced. To our knowledge, this is the first Polish case report of adult patients with Gorham-Stout disease.

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