Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature

Gorham-Stout disease (GSD) is a very rare, life-threatening condition characterized by the proliferation of lymphatic vessels and osteolysis. Unfortunately, no standard treatment has been determined for management of GSD. The available therapies are not equally effective and carry substantial side-e...

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Autores principales: Wojciechowska-Durczynska, Katarzyna, Zygmunt, Arkadiusz, Mikulak, Marta, Ludwisiak, Marta, Lewinski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517245/
https://www.ncbi.nlm.nih.gov/pubmed/36141975
http://dx.doi.org/10.3390/ijerph191811692
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author Wojciechowska-Durczynska, Katarzyna
Zygmunt, Arkadiusz
Mikulak, Marta
Ludwisiak, Marta
Lewinski, Andrzej
author_facet Wojciechowska-Durczynska, Katarzyna
Zygmunt, Arkadiusz
Mikulak, Marta
Ludwisiak, Marta
Lewinski, Andrzej
author_sort Wojciechowska-Durczynska, Katarzyna
collection PubMed
description Gorham-Stout disease (GSD) is a very rare, life-threatening condition characterized by the proliferation of lymphatic vessels and osteolysis. Unfortunately, no standard treatment has been determined for management of GSD. The available therapies are not equally effective and carry substantial side-effects. We report a 42-year-old female with GSD manifested in multifocal osteolysis and chronic chylothorax and ascites. The combined treatment with sirolimus and zoledronic acid due to its synergism of action was introduced. To our knowledge, this is the first Polish case report of adult patients with Gorham-Stout disease.
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spelling pubmed-95172452022-09-29 Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature Wojciechowska-Durczynska, Katarzyna Zygmunt, Arkadiusz Mikulak, Marta Ludwisiak, Marta Lewinski, Andrzej Int J Environ Res Public Health Case Report Gorham-Stout disease (GSD) is a very rare, life-threatening condition characterized by the proliferation of lymphatic vessels and osteolysis. Unfortunately, no standard treatment has been determined for management of GSD. The available therapies are not equally effective and carry substantial side-effects. We report a 42-year-old female with GSD manifested in multifocal osteolysis and chronic chylothorax and ascites. The combined treatment with sirolimus and zoledronic acid due to its synergism of action was introduced. To our knowledge, this is the first Polish case report of adult patients with Gorham-Stout disease. MDPI 2022-09-16 /pmc/articles/PMC9517245/ /pubmed/36141975 http://dx.doi.org/10.3390/ijerph191811692 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Wojciechowska-Durczynska, Katarzyna
Zygmunt, Arkadiusz
Mikulak, Marta
Ludwisiak, Marta
Lewinski, Andrzej
Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature
title Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature
title_full Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature
title_fullStr Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature
title_full_unstemmed Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature
title_short Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature
title_sort difficult therapeutic decisions in gorham-stout disease–case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517245/
https://www.ncbi.nlm.nih.gov/pubmed/36141975
http://dx.doi.org/10.3390/ijerph191811692
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