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The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial

The current study investigated the impact of different doses of Nigella sativa seeds on the symptoms, the cluster of differentiation profile group, and inflammatory markers of mild COVID-19 cases. Methods: The study was a double-blind placebo-controlled clinical trial. Patients with mild and asympto...

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Autores principales: Bin Abdulrahman, Khalid A., Bamosa, Abdullah Omar, Bukhari, Abdullah I., Siddiqui, Intisar Ahmad, Arafa, Mostafa A., Mohsin, Ashfaq A., Althageel, Mamdouh Faleh, Aljuaeed, Majed Owed, Aldeailej, Ibrahim Mohammed, Alrajeh, Abdulaziz Ibrahim, Aldosari, Kamel Mohamed, Hawsawi, Najat Ahmed, Zawbaee, Khalid Ibrahim, Alsurayea, Saad Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517329/
https://www.ncbi.nlm.nih.gov/pubmed/36142070
http://dx.doi.org/10.3390/ijerph191811798
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author Bin Abdulrahman, Khalid A.
Bamosa, Abdullah Omar
Bukhari, Abdullah I.
Siddiqui, Intisar Ahmad
Arafa, Mostafa A.
Mohsin, Ashfaq A.
Althageel, Mamdouh Faleh
Aljuaeed, Majed Owed
Aldeailej, Ibrahim Mohammed
Alrajeh, Abdulaziz Ibrahim
Aldosari, Kamel Mohamed
Hawsawi, Najat Ahmed
Zawbaee, Khalid Ibrahim
Alsurayea, Saad Mohammed
author_facet Bin Abdulrahman, Khalid A.
Bamosa, Abdullah Omar
Bukhari, Abdullah I.
Siddiqui, Intisar Ahmad
Arafa, Mostafa A.
Mohsin, Ashfaq A.
Althageel, Mamdouh Faleh
Aljuaeed, Majed Owed
Aldeailej, Ibrahim Mohammed
Alrajeh, Abdulaziz Ibrahim
Aldosari, Kamel Mohamed
Hawsawi, Najat Ahmed
Zawbaee, Khalid Ibrahim
Alsurayea, Saad Mohammed
author_sort Bin Abdulrahman, Khalid A.
collection PubMed
description The current study investigated the impact of different doses of Nigella sativa seeds on the symptoms, the cluster of differentiation profile group, and inflammatory markers of mild COVID-19 cases. Methods: The study was a double-blind placebo-controlled clinical trial. Patients with mild and asymptomatic SARS-CoV-2 infection patients were randomly subdivided into seven subgroups: Group (GP) 1: received charcoal capsules as a control group, and GP 2: received three capsules of whole Nigella sativa seeds daily, two capsules in the morning and one in the evening; GP 3: received three capsules of whole Nigella sativa seeds every 12 h, GP 4: received five capsules in the morning and four capsules of whole Nigella sativa seeds in the evening, GP 5: received one capsule of Nigella sativa powder every 12 h; GP 6: received two capsules of Nigella sativa powder every 12 h; GP 7: received three capsules of Nigella sativa powder every 12 h; all treatment course was for ten days. Inflammatory parameters were assessed before and after interventions. Results: 262 subjects were included in the final analysis. No significant difference was detected regarding age, gender, and nationality. No significant differences were detected between the inflammatory marker in all groups. The WBCs showed a significant difference between before and after the intervention. While for procalcitonin, a significant difference was demonstrated in groups 1,4, and 6. Conclusions: The current randomized clinical trial did not reveal a significant effect of ten days of treatment with various doses of Nigella sativa on symptoms, differentiation profile, and inflammatory markers of patients with COVID-19. As a natural product, the effect of Nigella sativa on disease requires weeks to manifest itself.
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spelling pubmed-95173292022-09-29 The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial Bin Abdulrahman, Khalid A. Bamosa, Abdullah Omar Bukhari, Abdullah I. Siddiqui, Intisar Ahmad Arafa, Mostafa A. Mohsin, Ashfaq A. Althageel, Mamdouh Faleh Aljuaeed, Majed Owed Aldeailej, Ibrahim Mohammed Alrajeh, Abdulaziz Ibrahim Aldosari, Kamel Mohamed Hawsawi, Najat Ahmed Zawbaee, Khalid Ibrahim Alsurayea, Saad Mohammed Int J Environ Res Public Health Article The current study investigated the impact of different doses of Nigella sativa seeds on the symptoms, the cluster of differentiation profile group, and inflammatory markers of mild COVID-19 cases. Methods: The study was a double-blind placebo-controlled clinical trial. Patients with mild and asymptomatic SARS-CoV-2 infection patients were randomly subdivided into seven subgroups: Group (GP) 1: received charcoal capsules as a control group, and GP 2: received three capsules of whole Nigella sativa seeds daily, two capsules in the morning and one in the evening; GP 3: received three capsules of whole Nigella sativa seeds every 12 h, GP 4: received five capsules in the morning and four capsules of whole Nigella sativa seeds in the evening, GP 5: received one capsule of Nigella sativa powder every 12 h; GP 6: received two capsules of Nigella sativa powder every 12 h; GP 7: received three capsules of Nigella sativa powder every 12 h; all treatment course was for ten days. Inflammatory parameters were assessed before and after interventions. Results: 262 subjects were included in the final analysis. No significant difference was detected regarding age, gender, and nationality. No significant differences were detected between the inflammatory marker in all groups. The WBCs showed a significant difference between before and after the intervention. While for procalcitonin, a significant difference was demonstrated in groups 1,4, and 6. Conclusions: The current randomized clinical trial did not reveal a significant effect of ten days of treatment with various doses of Nigella sativa on symptoms, differentiation profile, and inflammatory markers of patients with COVID-19. As a natural product, the effect of Nigella sativa on disease requires weeks to manifest itself. MDPI 2022-09-19 /pmc/articles/PMC9517329/ /pubmed/36142070 http://dx.doi.org/10.3390/ijerph191811798 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bin Abdulrahman, Khalid A.
Bamosa, Abdullah Omar
Bukhari, Abdullah I.
Siddiqui, Intisar Ahmad
Arafa, Mostafa A.
Mohsin, Ashfaq A.
Althageel, Mamdouh Faleh
Aljuaeed, Majed Owed
Aldeailej, Ibrahim Mohammed
Alrajeh, Abdulaziz Ibrahim
Aldosari, Kamel Mohamed
Hawsawi, Najat Ahmed
Zawbaee, Khalid Ibrahim
Alsurayea, Saad Mohammed
The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial
title The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial
title_full The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial
title_fullStr The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial
title_full_unstemmed The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial
title_short The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial
title_sort effect of short treatment with nigella sativa on symptoms, the cluster of differentiation (cd) profile, and inflammatory markers in mild covid-19 patients: a randomized, double-blind controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517329/
https://www.ncbi.nlm.nih.gov/pubmed/36142070
http://dx.doi.org/10.3390/ijerph191811798
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