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The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial
The current study investigated the impact of different doses of Nigella sativa seeds on the symptoms, the cluster of differentiation profile group, and inflammatory markers of mild COVID-19 cases. Methods: The study was a double-blind placebo-controlled clinical trial. Patients with mild and asympto...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517329/ https://www.ncbi.nlm.nih.gov/pubmed/36142070 http://dx.doi.org/10.3390/ijerph191811798 |
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author | Bin Abdulrahman, Khalid A. Bamosa, Abdullah Omar Bukhari, Abdullah I. Siddiqui, Intisar Ahmad Arafa, Mostafa A. Mohsin, Ashfaq A. Althageel, Mamdouh Faleh Aljuaeed, Majed Owed Aldeailej, Ibrahim Mohammed Alrajeh, Abdulaziz Ibrahim Aldosari, Kamel Mohamed Hawsawi, Najat Ahmed Zawbaee, Khalid Ibrahim Alsurayea, Saad Mohammed |
author_facet | Bin Abdulrahman, Khalid A. Bamosa, Abdullah Omar Bukhari, Abdullah I. Siddiqui, Intisar Ahmad Arafa, Mostafa A. Mohsin, Ashfaq A. Althageel, Mamdouh Faleh Aljuaeed, Majed Owed Aldeailej, Ibrahim Mohammed Alrajeh, Abdulaziz Ibrahim Aldosari, Kamel Mohamed Hawsawi, Najat Ahmed Zawbaee, Khalid Ibrahim Alsurayea, Saad Mohammed |
author_sort | Bin Abdulrahman, Khalid A. |
collection | PubMed |
description | The current study investigated the impact of different doses of Nigella sativa seeds on the symptoms, the cluster of differentiation profile group, and inflammatory markers of mild COVID-19 cases. Methods: The study was a double-blind placebo-controlled clinical trial. Patients with mild and asymptomatic SARS-CoV-2 infection patients were randomly subdivided into seven subgroups: Group (GP) 1: received charcoal capsules as a control group, and GP 2: received three capsules of whole Nigella sativa seeds daily, two capsules in the morning and one in the evening; GP 3: received three capsules of whole Nigella sativa seeds every 12 h, GP 4: received five capsules in the morning and four capsules of whole Nigella sativa seeds in the evening, GP 5: received one capsule of Nigella sativa powder every 12 h; GP 6: received two capsules of Nigella sativa powder every 12 h; GP 7: received three capsules of Nigella sativa powder every 12 h; all treatment course was for ten days. Inflammatory parameters were assessed before and after interventions. Results: 262 subjects were included in the final analysis. No significant difference was detected regarding age, gender, and nationality. No significant differences were detected between the inflammatory marker in all groups. The WBCs showed a significant difference between before and after the intervention. While for procalcitonin, a significant difference was demonstrated in groups 1,4, and 6. Conclusions: The current randomized clinical trial did not reveal a significant effect of ten days of treatment with various doses of Nigella sativa on symptoms, differentiation profile, and inflammatory markers of patients with COVID-19. As a natural product, the effect of Nigella sativa on disease requires weeks to manifest itself. |
format | Online Article Text |
id | pubmed-9517329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95173292022-09-29 The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial Bin Abdulrahman, Khalid A. Bamosa, Abdullah Omar Bukhari, Abdullah I. Siddiqui, Intisar Ahmad Arafa, Mostafa A. Mohsin, Ashfaq A. Althageel, Mamdouh Faleh Aljuaeed, Majed Owed Aldeailej, Ibrahim Mohammed Alrajeh, Abdulaziz Ibrahim Aldosari, Kamel Mohamed Hawsawi, Najat Ahmed Zawbaee, Khalid Ibrahim Alsurayea, Saad Mohammed Int J Environ Res Public Health Article The current study investigated the impact of different doses of Nigella sativa seeds on the symptoms, the cluster of differentiation profile group, and inflammatory markers of mild COVID-19 cases. Methods: The study was a double-blind placebo-controlled clinical trial. Patients with mild and asymptomatic SARS-CoV-2 infection patients were randomly subdivided into seven subgroups: Group (GP) 1: received charcoal capsules as a control group, and GP 2: received three capsules of whole Nigella sativa seeds daily, two capsules in the morning and one in the evening; GP 3: received three capsules of whole Nigella sativa seeds every 12 h, GP 4: received five capsules in the morning and four capsules of whole Nigella sativa seeds in the evening, GP 5: received one capsule of Nigella sativa powder every 12 h; GP 6: received two capsules of Nigella sativa powder every 12 h; GP 7: received three capsules of Nigella sativa powder every 12 h; all treatment course was for ten days. Inflammatory parameters were assessed before and after interventions. Results: 262 subjects were included in the final analysis. No significant difference was detected regarding age, gender, and nationality. No significant differences were detected between the inflammatory marker in all groups. The WBCs showed a significant difference between before and after the intervention. While for procalcitonin, a significant difference was demonstrated in groups 1,4, and 6. Conclusions: The current randomized clinical trial did not reveal a significant effect of ten days of treatment with various doses of Nigella sativa on symptoms, differentiation profile, and inflammatory markers of patients with COVID-19. As a natural product, the effect of Nigella sativa on disease requires weeks to manifest itself. MDPI 2022-09-19 /pmc/articles/PMC9517329/ /pubmed/36142070 http://dx.doi.org/10.3390/ijerph191811798 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bin Abdulrahman, Khalid A. Bamosa, Abdullah Omar Bukhari, Abdullah I. Siddiqui, Intisar Ahmad Arafa, Mostafa A. Mohsin, Ashfaq A. Althageel, Mamdouh Faleh Aljuaeed, Majed Owed Aldeailej, Ibrahim Mohammed Alrajeh, Abdulaziz Ibrahim Aldosari, Kamel Mohamed Hawsawi, Najat Ahmed Zawbaee, Khalid Ibrahim Alsurayea, Saad Mohammed The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial |
title | The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial |
title_full | The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial |
title_fullStr | The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial |
title_full_unstemmed | The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial |
title_short | The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial |
title_sort | effect of short treatment with nigella sativa on symptoms, the cluster of differentiation (cd) profile, and inflammatory markers in mild covid-19 patients: a randomized, double-blind controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517329/ https://www.ncbi.nlm.nih.gov/pubmed/36142070 http://dx.doi.org/10.3390/ijerph191811798 |
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