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The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan

Background: There are several possible links that have been used to claim that osteoporosis and peripheral artery disease (PAD) are associated; however, the solid evidence is not sufficient. This study aimed to use the Taiwan National Health Insurance Research Database (NHIRD) to determine if osteop...

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Autores principales: Syu, De-Kai, Hsu, Shu-Hua, Yeh, Ping-Chun, Lee, Tsung-Lin, Kuo, Yu-Feng, Huang, Yen-Chun, Jiang, Ching-Chuan, Chen, Mingchih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517417/
https://www.ncbi.nlm.nih.gov/pubmed/36141599
http://dx.doi.org/10.3390/ijerph191811327
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author Syu, De-Kai
Hsu, Shu-Hua
Yeh, Ping-Chun
Lee, Tsung-Lin
Kuo, Yu-Feng
Huang, Yen-Chun
Jiang, Ching-Chuan
Chen, Mingchih
author_facet Syu, De-Kai
Hsu, Shu-Hua
Yeh, Ping-Chun
Lee, Tsung-Lin
Kuo, Yu-Feng
Huang, Yen-Chun
Jiang, Ching-Chuan
Chen, Mingchih
author_sort Syu, De-Kai
collection PubMed
description Background: There are several possible links that have been used to claim that osteoporosis and peripheral artery disease (PAD) are associated; however, the solid evidence is not sufficient. This study aimed to use the Taiwan National Health Insurance Research Database (NHIRD) to determine if osteoporosis is associated with peripheral artery disease (PAD). Method: NHIRD records from 23 million patients were collected to recruit two matched cohort groups: 64,562 patients with and 64,562 patients without osteoporosis. To compare the crude hazard ratio (HR) and the incidence rate ratio between the two cohort groups for PAD, the Cox model was used. Result: With an adjusted HR of 1.18 (95% CI, 1.08–1.29), the osteoporosis cohort group had a significantly greater risk for PAD than the group without osteoporosis. The cumulative incidence of PAD in the cohort group was also statistically higher than it was in the group without osteoporosis (1.71% and 1.39%; p ≤ 0.0001, log-rank) over the 10-year follow-up period. In addition, the osteoporotic patients with ischemic stroke, chronic obstructive pulmonary disease (COPD), and congestive heart failure (CHF) had a significantly increased risk of PAD based on subgroup analysis. Conclusions: There was a positive association between osteoporosis and the development of PAD, as patients with osteoporosis had an increased incidence of PAD over time.
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spelling pubmed-95174172022-09-29 The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan Syu, De-Kai Hsu, Shu-Hua Yeh, Ping-Chun Lee, Tsung-Lin Kuo, Yu-Feng Huang, Yen-Chun Jiang, Ching-Chuan Chen, Mingchih Int J Environ Res Public Health Article Background: There are several possible links that have been used to claim that osteoporosis and peripheral artery disease (PAD) are associated; however, the solid evidence is not sufficient. This study aimed to use the Taiwan National Health Insurance Research Database (NHIRD) to determine if osteoporosis is associated with peripheral artery disease (PAD). Method: NHIRD records from 23 million patients were collected to recruit two matched cohort groups: 64,562 patients with and 64,562 patients without osteoporosis. To compare the crude hazard ratio (HR) and the incidence rate ratio between the two cohort groups for PAD, the Cox model was used. Result: With an adjusted HR of 1.18 (95% CI, 1.08–1.29), the osteoporosis cohort group had a significantly greater risk for PAD than the group without osteoporosis. The cumulative incidence of PAD in the cohort group was also statistically higher than it was in the group without osteoporosis (1.71% and 1.39%; p ≤ 0.0001, log-rank) over the 10-year follow-up period. In addition, the osteoporotic patients with ischemic stroke, chronic obstructive pulmonary disease (COPD), and congestive heart failure (CHF) had a significantly increased risk of PAD based on subgroup analysis. Conclusions: There was a positive association between osteoporosis and the development of PAD, as patients with osteoporosis had an increased incidence of PAD over time. MDPI 2022-09-09 /pmc/articles/PMC9517417/ /pubmed/36141599 http://dx.doi.org/10.3390/ijerph191811327 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Syu, De-Kai
Hsu, Shu-Hua
Yeh, Ping-Chun
Lee, Tsung-Lin
Kuo, Yu-Feng
Huang, Yen-Chun
Jiang, Ching-Chuan
Chen, Mingchih
The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan
title The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan
title_full The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan
title_fullStr The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan
title_full_unstemmed The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan
title_short The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan
title_sort association between osteoporosis and peripheral artery disease: a population-based longitudinal follow-up study in taiwan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517417/
https://www.ncbi.nlm.nih.gov/pubmed/36141599
http://dx.doi.org/10.3390/ijerph191811327
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