Cargando…

Association between 3-Year Repetitive Isolated Hematuria and eGFR Deterioration in an Apparently Healthy Population: A Retrospective Cohort Study

Microscopic hematuria is being increasingly recognized as a major indicator of kidney deterioration. Persistent hematuria may better detect estimated glomerular filtration rate (eGFR) deterioration and potential glomerulonephritis. We conducted a retrospective cohort study to investigate the associa...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishida, Mami, Matsuzaki, Keiichi, Suzuki, Hitoshi, Suzuki, Yusuke, Kawamura, Takashi, Marunaka, Yoshinori, Iwami, Taku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517453/
https://www.ncbi.nlm.nih.gov/pubmed/36141738
http://dx.doi.org/10.3390/ijerph191811466
_version_ 1784798946318614528
author Ishida, Mami
Matsuzaki, Keiichi
Suzuki, Hitoshi
Suzuki, Yusuke
Kawamura, Takashi
Marunaka, Yoshinori
Iwami, Taku
author_facet Ishida, Mami
Matsuzaki, Keiichi
Suzuki, Hitoshi
Suzuki, Yusuke
Kawamura, Takashi
Marunaka, Yoshinori
Iwami, Taku
author_sort Ishida, Mami
collection PubMed
description Microscopic hematuria is being increasingly recognized as a major indicator of kidney deterioration. Persistent hematuria may better detect estimated glomerular filtration rate (eGFR) deterioration and potential glomerulonephritis. We conducted a retrospective cohort study to investigate the associations between persistent hematuria: the frequency or consistency of positive dipstick hematuria defined by the preceding 3 years urinalyses, and eGFR deterioration over 5 years and abnormal urinalyses suggesting potential glomerulonephritis (hematuria 1+ or higher, 2+ or higher, proteinuria, and hematuria and proteinuria) 5 years later, among adult participants with positive dipstick hematuria at baseline in a large-scale Japanese health checkup setting (n = 2104). There was no significant association between persistent hematuria and eGFR deterioration over 5 years. The higher the frequency of preceding hematuria, the greater the RR of hematuria 5 years later; RRs of hematuria with preceding thrice, twice, or once hematuria were 3.64 [95% CI, 3.11–4.25], 2.97 [95% CI, 2.52–3.51], or 1.91 [95% CI, 1.58–2.30] for “hematuria 1+ or higher,” and 7.13 [95% CI, 5.17–9.83], 4.26 [95% CI, 3.02–6.02], or 2.23 [95% CI, 1.52–3.27] for “hematuria 2+ or higher”. The presence of both hematuria and proteinuria 5 years later was only associated with preceding thrice hematuria (RR: 2.35 [95% CI, 1.37–4.03]). In conclusion, persistent hematuria for 3 years was associated with hematuria and proteinuria that were suggesting glomerulonephritis, but not associated with eGFR deterioration over 5 years. Multiple dipstick urinalyses over years can add some values to detect potential glomerulonephritis as an early sign of chronic kidney diseases.
format Online
Article
Text
id pubmed-9517453
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95174532022-09-29 Association between 3-Year Repetitive Isolated Hematuria and eGFR Deterioration in an Apparently Healthy Population: A Retrospective Cohort Study Ishida, Mami Matsuzaki, Keiichi Suzuki, Hitoshi Suzuki, Yusuke Kawamura, Takashi Marunaka, Yoshinori Iwami, Taku Int J Environ Res Public Health Article Microscopic hematuria is being increasingly recognized as a major indicator of kidney deterioration. Persistent hematuria may better detect estimated glomerular filtration rate (eGFR) deterioration and potential glomerulonephritis. We conducted a retrospective cohort study to investigate the associations between persistent hematuria: the frequency or consistency of positive dipstick hematuria defined by the preceding 3 years urinalyses, and eGFR deterioration over 5 years and abnormal urinalyses suggesting potential glomerulonephritis (hematuria 1+ or higher, 2+ or higher, proteinuria, and hematuria and proteinuria) 5 years later, among adult participants with positive dipstick hematuria at baseline in a large-scale Japanese health checkup setting (n = 2104). There was no significant association between persistent hematuria and eGFR deterioration over 5 years. The higher the frequency of preceding hematuria, the greater the RR of hematuria 5 years later; RRs of hematuria with preceding thrice, twice, or once hematuria were 3.64 [95% CI, 3.11–4.25], 2.97 [95% CI, 2.52–3.51], or 1.91 [95% CI, 1.58–2.30] for “hematuria 1+ or higher,” and 7.13 [95% CI, 5.17–9.83], 4.26 [95% CI, 3.02–6.02], or 2.23 [95% CI, 1.52–3.27] for “hematuria 2+ or higher”. The presence of both hematuria and proteinuria 5 years later was only associated with preceding thrice hematuria (RR: 2.35 [95% CI, 1.37–4.03]). In conclusion, persistent hematuria for 3 years was associated with hematuria and proteinuria that were suggesting glomerulonephritis, but not associated with eGFR deterioration over 5 years. Multiple dipstick urinalyses over years can add some values to detect potential glomerulonephritis as an early sign of chronic kidney diseases. MDPI 2022-09-12 /pmc/articles/PMC9517453/ /pubmed/36141738 http://dx.doi.org/10.3390/ijerph191811466 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ishida, Mami
Matsuzaki, Keiichi
Suzuki, Hitoshi
Suzuki, Yusuke
Kawamura, Takashi
Marunaka, Yoshinori
Iwami, Taku
Association between 3-Year Repetitive Isolated Hematuria and eGFR Deterioration in an Apparently Healthy Population: A Retrospective Cohort Study
title Association between 3-Year Repetitive Isolated Hematuria and eGFR Deterioration in an Apparently Healthy Population: A Retrospective Cohort Study
title_full Association between 3-Year Repetitive Isolated Hematuria and eGFR Deterioration in an Apparently Healthy Population: A Retrospective Cohort Study
title_fullStr Association between 3-Year Repetitive Isolated Hematuria and eGFR Deterioration in an Apparently Healthy Population: A Retrospective Cohort Study
title_full_unstemmed Association between 3-Year Repetitive Isolated Hematuria and eGFR Deterioration in an Apparently Healthy Population: A Retrospective Cohort Study
title_short Association between 3-Year Repetitive Isolated Hematuria and eGFR Deterioration in an Apparently Healthy Population: A Retrospective Cohort Study
title_sort association between 3-year repetitive isolated hematuria and egfr deterioration in an apparently healthy population: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517453/
https://www.ncbi.nlm.nih.gov/pubmed/36141738
http://dx.doi.org/10.3390/ijerph191811466
work_keys_str_mv AT ishidamami associationbetween3yearrepetitiveisolatedhematuriaandegfrdeteriorationinanapparentlyhealthypopulationaretrospectivecohortstudy
AT matsuzakikeiichi associationbetween3yearrepetitiveisolatedhematuriaandegfrdeteriorationinanapparentlyhealthypopulationaretrospectivecohortstudy
AT suzukihitoshi associationbetween3yearrepetitiveisolatedhematuriaandegfrdeteriorationinanapparentlyhealthypopulationaretrospectivecohortstudy
AT suzukiyusuke associationbetween3yearrepetitiveisolatedhematuriaandegfrdeteriorationinanapparentlyhealthypopulationaretrospectivecohortstudy
AT kawamuratakashi associationbetween3yearrepetitiveisolatedhematuriaandegfrdeteriorationinanapparentlyhealthypopulationaretrospectivecohortstudy
AT marunakayoshinori associationbetween3yearrepetitiveisolatedhematuriaandegfrdeteriorationinanapparentlyhealthypopulationaretrospectivecohortstudy
AT iwamitaku associationbetween3yearrepetitiveisolatedhematuriaandegfrdeteriorationinanapparentlyhealthypopulationaretrospectivecohortstudy